{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:22:39Z","timestamp":1790702559158,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T00:00:00Z","timestamp":1431043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Cervical cancer and its precursor lesions are caused by a persistent high\u2010risk human papillomavirus (hrHPV) infection. hrHPV testing has been reported to have higher sensitivity than Papanicolaou (Pap) testing for the detection of cervical precursor lesions. However, limited data are available for prior human papillomavirus (HPV) testing results for patients later diagnosed with invasive cervical cancer, especially in countries lacking a national cervical cancer screening program such as China. This study investigated prior hrHPV testing results for patients with invasive cervical cancer in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Cases with a histologic diagnosis of invasive cervical carcinoma were retrieved from Guangzhou KingMed Diagnostics (the largest independent pathology laboratory in China); prior hrHPV and Pap test results obtained within the year before the cancer diagnosis were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>HPV testing was negative in 7.5% of 427 cases of invasive cervical carcinoma, including squamous cell carcinoma (5%) and adenocarcinoma (25%). In 155 cervical cancer cases with prior hrHPV and Pap testing, the negative rate for Pap testing was 1.9%, and the negative rate for HPV was 9.7%. Furthermore, when only cases of adenocarcinoma (n\u2009=\u200918) were examined, both the hrHPV\u2010negative rate and the Pap\u2010negative rate were higher at 33% and 5.6%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>These data demonstrate a considerable prior hrHPV\u2010negative rate and a lower prior Pap\u2010negative rate in patients with invasive cervical carcinoma (especially adenocarcinoma) from a population of women without access to an established screening program. <jats:bold><jats:italic>Cancer (Cancer Cytopathol)<\/jats:italic> 2015;123:428\u201034.<\/jats:bold> \u00a9 <jats:italic>2015 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21557","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T11:41:58Z","timestamp":1431085318000},"page":"428-434","source":"Crossref","is-referenced-by-count":32,"title":["Prior high\u2010risk <scp>HPV<\/scp> testing and <scp>P<\/scp>ap test results for 427 invasive cervical cancers in China's largest <scp>CAP<\/scp>\u2010certified laboratory"],"prefix":"10.1002","volume":"123","author":[{"given":"Baowen","family":"Zheng","sequence":"first","affiliation":[{"name":"Guangzhou KingMed Diagnostics  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaibo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Wexner Medical Center, Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Pathology Magee\u2010Womens Hospital, University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Yan","sequence":"additional","affiliation":[{"name":"Guangzhou KingMed Diagnostics  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congde","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangzhou KingMed Diagnostics  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Ding","sequence":"additional","affiliation":[{"name":"Guangzhou KingMed Diagnostics  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoman","family":"Liang","sequence":"additional","affiliation":[{"name":"Guangzhou KingMed Diagnostics  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaitao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Cincinnati Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of 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