{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T08:52:37Z","timestamp":1783759957803,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T00:00:00Z","timestamp":1435795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Epithelioid inflammatory myofibroblastic sarcoma (E\u2010IMS) is a recently established rare variant of inflammatory myofibroblastic tumor. It is characterized by a distinctive constellation of clinical, pathological, and molecular features, including a nearly exclusive intraabdominal location, strong male predilection, aggressive clinical course, predominance of epithelioid tumor cells, and Ran\u2010binding protein 2 (<jats:italic>RANBP2<\/jats:italic>)<jats:italic>\u2010<\/jats:italic>anaplastic lymphoma kinase (<jats:italic>ALK<\/jats:italic>) fusion in the majority of cases. To the authors\u2019 knowledge, the cytologic features of E\u2010IMS have not been described to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Cases of E\u2010IMS that had corresponding cytology were searched. Six cytology samples (1 fine\u2010needle aspiration sample, 2 imprint samples, and 3 effusion fluids) containing tumor cells were identified in 5 patients with E\u2010IMS.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The cytomorphology included large monotonous epithelioid cells arranged in loose aggregates or singly, with admixed myxoid stroma, and an inflammatory background rich in neutrophils. The tumor cells had a large, round, eccentric nucleus with vesicular chromatin, prominent nucleoli, and moderate amounts of pale cytoplasm. Delicate thin\u2010walled branching vessels traversing tumor aggregates was a prominent feature in a fine\u2010needle aspiration sample. Immunohistochemically, ALK was positive in all 5 tumors, with a nuclear membranous staining pattern noted in 3 cases and a cytoplasmic pattern observed in the other 2 cases. <jats:italic>ALK<\/jats:italic> rearrangement was confirmed in all 5 tumors by molecular genetic studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The cytologic features of E\u2010IMS recapitulate its histologic characteristics. E\u2010IMS merits inclusion in the differential diagnosis of any intraabdominal, large epithelioid cell neoplasm. Confirmation of <jats:italic>ALK<\/jats:italic> rearrangement is advisable because patients may benefit from targeted therapies. <jats:bold><jats:italic>Cancer (Cancer Cytopathol)<\/jats:italic> 2015;123:495\u2013504<\/jats:bold>. \u00a9 <jats:italic>2015 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21558","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T09:09:54Z","timestamp":1435828194000},"page":"495-504","source":"Crossref","is-referenced-by-count":26,"title":["Cytopathologic features of epithelioid inflammatory myofibroblastic sarcoma with correlation of histopathology, immunohistochemistry, and molecular cytogenetic analysis"],"prefix":"10.1002","volume":"123","author":[{"given":"Jen\u2010Chieh","family":"Lee","sequence":"first","affiliation":[{"name":"Department and Graduate Institute of Pathology National Taiwan University Hospital National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiann\u2010Ming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Surgery Far Eastern Memorial Hospital New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jau\u2010Yu","family":"Liau","sequence":"additional","affiliation":[{"name":"Department and Graduate Institute of Pathology National Taiwan University Hospital National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan\u2010Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Yu","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Pathology Far Eastern Memorial Hospital New Taipei City 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