{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T08:12:24Z","timestamp":1768983144812,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T00:00:00Z","timestamp":1438905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Mammary analogue secretory carcinoma (MASC) with an ETS variant gene 6 (<jats:italic>ETV6<\/jats:italic>)\u2013neurotrophic tyrosine kinase receptor type 3 (<jats:italic>NTRK3<\/jats:italic>) translocation is a newly described type of salivary gland cancer. It is known that overexpression of signal transducer and activator of transcription 5a (STAT5a) occurs in secretory carcinoma of the breast and MASC, and STAT5a expression may be related to the <jats:italic>ETV6<\/jats:italic>\u2010<jats:italic>NTRK3<\/jats:italic> translocation. It was hypothesized that phosphorylated signal transducer and activator of transcription 5 (p\u2010STAT5) might be specifically expressed in MASC of the salivary gland.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The expression of p\u2010STAT5 and mammaglobin (MMG) was examined with immunohistochemistry (IHC)\/immunocytochemistry (ICC) in tissue sections from 58 salivary gland cancers (8 MASCs and 50 other salivary gland cancers) and in cytological smears from 17 salivary gland cancers (7 MASCs with paired histologic samples and 10 other salivary gland cancers).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>p\u2010STAT5 IHC was clearly increased in MASC versus normal salivary gland tissue and other salivary gland cancers. p\u2010STAT5 expression was found in 7 of 8 MASCs (87.5%) and in none of the 50 other salivary gland cancers (0%) by IHC. On cytology, p\u2010STAT5 expression was found in all cases of MASC (7 of 7 or 100%) but in none of the 10 other salivary gland cancers (0%) by ICC. The expression rate of MMG by histology and cytology was higher than that of p\u2010STAT5 in the other salivary gland cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>p\u2010STAT5 might be useful as a detection marker of MASC in the differential diagnosis of salivary gland cancers, and initial screening with p\u2010STAT5 IHC\/ICC, combined with auxiliary fluorescence in situ hybridization confirmation, is a reliable, economical approach to identifying MASC of the salivary gland. <jats:bold><jats:italic>Cancer (Cancer Cytopathol)<\/jats:italic> 2015;123:603\u201311<\/jats:bold>. \u00a9 <jats:italic>2015 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21594","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T09:39:37Z","timestamp":1438940377000},"page":"603-611","source":"Crossref","is-referenced-by-count":32,"title":["Diagnostic utility of phosphorylated signal transducer and activator of transcription 5 immunostaining in the diagnosis of mammary analogue secretory carcinoma of the salivary gland: A comparative study of salivary gland cancers"],"prefix":"10.1002","volume":"123","author":[{"given":"Akihiko","family":"Kawahara","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Kurume University Hospital Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Taira","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kurume University Hospital Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kurume University Hospital Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yorihiko","family":"Takase","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kurume University 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