{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T11:27:47Z","timestamp":1786793267275,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T00:00:00Z","timestamp":1438300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Canadian Institutes of Health Research (CIHR)","award":["MCT-54063 to Dr. Franco"],"award-info":[{"award-number":["MCT-54063 to Dr. Franco"]}]},{"name":"CIHR team","award":["83320 to Dr. Franco"],"award-info":[{"award-number":["83320 to Dr. Franco"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Knowledge of cervical human papillomavirus (HPV) status might influence a cytotechnician's assessment of cellular abnormalities. The authors compared original cytotechnicians' Papanicolaou (Pap) readings for which HPV status was concealed with Pap rereads for which HPV status was revealed separately for 3 screening populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Previously collected cervical Pap smears and clinical data were obtained from the Canadian Cervical Cancer Screening Trial (study A), the Democratic Republic of Congo Community\u2010Based Screening Study (study B), and the Brazilian Investigation into Nutrition and Cervical Cancer Prevention (study C). Smears were reread with knowledge of HPV status for all HPV\u2010positive women as well as a sample of HPV\u2010negative women. Diagnostic performance of Pap cytology was compared between original readings and rereads.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 1767 Pap tests were reread. Among 915 rereads for HPV\u2010positive women, the contrast between \u201crevealed\u201d and \u201cconcealed\u201d Pap readings demonstrated revisions from negative to positive results for 109 women (cutoff was atypical squamous cells of undetermined significance or worse) and 124 women (cutoff was low\u2010grade squamous intraepithelial lesions [LSIL] or worse). For a disease threshold of cervical intraepithelial neoplasia of grade 2 or worse, specificity significantly declined at the atypical squamous cells of undetermined significance cutoff for studies A (86.6% to 75.3%) and C (42.5% to 15.5%), and at the LSIL cutoff for study C (61.9% to 37.6%). Sensitivity remained nearly unchanged between readings, except in study C, in which reread performance was superior (91.3% vs 71.9% for the LSIL cutoff).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>A reduction in the diagnostic accuracy of Pap cytology was observed when revealing patients' cervical HPV status, possibly due to a heightened awareness of potential abnormalities, which led to more false\u2010positive results. <jats:bold><jats:italic>Cancer (Cancer Cytopathol)<\/jats:italic> 2015;123:745\u2013754.<\/jats:bold> \u00a9 <jats:italic>2015 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21596","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T10:22:59Z","timestamp":1438338179000},"page":"745-754","source":"Crossref","is-referenced-by-count":46,"title":["HPV DNA testing with cytology triage in cervical cancer screening: Influence of revealing HPV infection status"],"prefix":"10.1002","volume":"123","author":[{"given":"Lyndsay Ann","family":"Richardson","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology, Department of Oncology McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"El\u2010Zein","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology, Department of Oncology McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnihotram V.","family":"Ramanakumar","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology, Department of Oncology McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Ratnam","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Memorial University St. John's, Newfoundland and Labrador Canada"},{"name":"Public Health Laboratory St. John's, 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Augusto","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Coutl\u00e9e","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Diseases Montreal University Medical Center Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo L.","family":"Franco","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology, Department of Oncology McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The PEACHS (Pap Efficacy After Cervical HPV Status) Study 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