{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:35:26Z","timestamp":1760315726734,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T00:00:00Z","timestamp":1441670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Rapid prescreening (RPS) is one of the quality assurance (QA) methods used in gynecologic cytology. The efficacy of RPS has been previously studied but mostly with respect to squamous lesions; in fact, there has been no study so far specifically looking at the sensitivity of RPS for detecting glandular cell abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 80,565 Papanicolaou (Pap) smears underwent RPS during a 25\u2010month period. A sample was designated as \u201creview for abnormality\u201d (R) if any abnormal cells (at the threshold of atypical squamous cells of undetermined significance\/atypical glandular cells [AGC]) were thought to be present or was designated as negative (N) if none were detected. Each sample then underwent full screening (FS) and was designated as either R or N and also given a cytologic interpretation.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The final cytologic interpretation was a glandular cell abnormality (\u2265AGC) in 107 samples (0.13%); 39 of these (36.4%) were flagged as R on RPS. Twenty\u2010four patients (33.8%) out of 71 who had histologic follow\u2010up were found to harbor a high\u2010grade squamous intraepithelial lesion or carcinoma; 13 of those 24 Pap smears (54.2%) had been flagged as R on RPS. Notably, 11 AGC cases were picked up by RPS only and not by FS and represented false\u2010negative cases; 2 of these showed endometrial adenocarcinoma on histologic follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Pap smears with glandular cell abnormalities are often flagged as abnormal by RPS, and this results in a sensitivity of 36.4% (at the AGC threshold). Most importantly, some cases of AGC are detected on Pap smears by RPS only, and this demonstrates that RPS is a valuable QA method. <jats:bold><jats:italic>Cancer (Cancer Cytopathol)<\/jats:italic> 2015;123:739\u2013744.<\/jats:bold> \u00a9 <jats:italic>2015 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21601","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T12:47:40Z","timestamp":1441716460000},"page":"739-744","source":"Crossref","is-referenced-by-count":1,"title":["<scp>P<\/scp>ap smears with glandular cell abnormalities: Are they detected by rapid prescreening?"],"prefix":"10.1002","volume":"123","author":[{"given":"Yonca","family":"Kanber","sequence":"first","affiliation":[{"name":"Department of Pathology McGill University Montreal Canada"},{"name":"Department of Pathology McGill University Health Center Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Charbonneau","sequence":"additional","affiliation":[{"name":"Department of Pathology McGill University Health Center Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manon","family":"Auger","sequence":"additional","affiliation":[{"name":"Department of Pathology McGill University Montreal Canada"},{"name":"Department of Pathology McGill University Health Center Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21424"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20189"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1001\/jama.1992.03480130031009","article-title":"Regulations for implementing Clinical Laboratory Improvement Amendments of 1988: a summary","volume":"267","author":"From the Centers for Disease Control","year":"1992","journal-title":"JAMA"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2006.00367.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.1998.00117.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328615"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.1991.tb00504.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.1993.tb00072.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.2003.00062.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.2001.00343.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.2002.00410.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22166"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20042"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e3182823849"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2008.00629.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.5858\/2004-128-1224-BIARRP"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20589"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-11074-5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/110.5.653"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0339(200008)23:2<127::AID-DC13>3.0.CO;2-I"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11826"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.07.008"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.05.019"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000202401.29145.68"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325117"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e318287d329"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2009.00718.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2005.08.009"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2008.00566.x"},{"key":"e_1_2_7_31_1","first-page":"587","article-title":"Rapid review (partial rescreening) of cervical cytology","volume":"49","author":"Faraker CA","year":"1996","journal-title":"Four years experience and quality assurance implications. 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