{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:57:52Z","timestamp":1764997072553,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>In recent years, high\u2010risk human papillomavirus (hrHPV) testing for triaging atypical squamous cells of undetermined significance and cotesting with cytology have been implemented in clinical practice. However, clinical data for primary screening with human papillomavirus (HPV) testing alone are currently lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This study retrospectively reviewed the correlation of cytology, histology, and hrHPV testing through the use of a cytology laboratory quality assurance database with 130,648 Papanicolaou (Pap) tests interpreted at Houston BioReference Laboratories and Houston Methodist Hospital between March 1, 2013 and June 30, 2014. Among the 47,499 patients who had undergone cytology\u2010HPV cotesting, 1654 underwent follow\u2010up biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The sensitivities of the hrHPV and Pap tests were 80.8% and 81.2%, respectively, for detecting any type of cervicovaginal dysplasia and 91.3% and 90.9%, respectively, for high\u2010grade cervicovaginal lesions. For biopsy\u2010confirmed high\u2010grade cervicovaginal lesions (cervical intraepithelial neoplasia grade 2+, adenocarcinoma in situ, or carcinoma; n = 253), the false\u2010negative rates for hrHPV and Pap tests were 8.7% and 9.1%, respectively. The false\u2010negative rate for cytology\u2010hrHPV cotesting was only 1.2%.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In clinical practice, the hrHPV test alone is not significantly superior to the Pap test as a primary screening method for cervicovaginal lesions. The false\u2010negative rate of the hrHPV test in detecting biopsy\u2010confirmed high\u2010grade cervicovaginal lesions is comparable to the rate of the Pap test. Women with cytology and hrHPV cotesting, however, have a significantly lower false\u2010negative rate than those undergoing either test alone. Currently, cytology\u2010HPV cotesting remains the best strategy for detecting high\u2010grade cervicovaginal lesions. <jats:bold><jats:italic>Cancer Cytopathol<\/jats:italic> 2016;124:317\u201323<\/jats:bold>. \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21687","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T17:01:26Z","timestamp":1452963686000},"page":"317-323","source":"Crossref","is-referenced-by-count":38,"title":["Clinical performance of the Food and Drug Administration\u2013Approved high\u2010risk HPV test for the detection of high\u2010grade cervicovaginal lesions"],"prefix":"10.1002","volume":"124","author":[{"given":"Haijun","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pathology and Genomic Medicine Houston Methodist Hospital Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxanne 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