{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T02:09:20Z","timestamp":1772503760824,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T00:00:00Z","timestamp":1460419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Human papillomavirus (HPV) DNA testing can be crucial for women who have limited access to traditional screening. The current study compared the results obtained through HPV DNA testing with those obtained through cytology\u2010based screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 3068 women aged 18 to 85 years were enrolled in an opportunistic cervical cancer screening program developed by the Barretos Cancer Hospital and performed by a team of health professionals working within a mobile unit from March to December 2012, followed by statistical analyses. For each patient, 2 different cervical samples were collected and preserved in a careHPV assay and SurePath medium, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>High\u2010risk HPV (hr\u2010HPV) DNA was detected in 10.0% of women, with the majority (86.7%) demonstrating no abnormal Papanicolaou test results. The following cytological samples were found to be hr\u2010HPV positive: 8.2% of the normal samples; 39.4% of the samples with atypical squamous\/glandular cells of undetermined significance; 38.5% of the samples with atypical squamous\/glandular cells of undetermined significance, cannot exclude high\u2010grade lesion; 55.3% of the samples with low\u2010grade squamous intraepithelial lesions; and 100% of the samples with high\u2010grade squamous intraepithelial lesions. Colposcopy examinations were performed among 33.4% of the women with positive results on at least 1 of the tests (HPV DNA positive and\/or cytology with atypical squamous\/glandular cells of undetermined significance, cannot exclude high\u2010grade lesion or high\u2010grade squamous intraepithelial lesions), and 59.5% of these women underwent biopsies. Among these samples, 18.2% were confirmed as cervical intraepithelial neoplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The careHPV test was demonstrated to be a feasible alternative to primary screening in low\u2010resource settings accessed through the use of mobile units. <jats:bold><jats:italic>Cancer Cytopathol<\/jats:italic> 2016;124:581\u20108<\/jats:bold>. \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21718","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T17:36:47Z","timestamp":1460482607000},"page":"581-588","source":"Crossref","is-referenced-by-count":18,"title":["Can the careHPV test performed in mobile units replace cytology for screening in rural and remote areas?"],"prefix":"10.1002","volume":"124","author":[{"given":"Adriana T.","family":"Lorenzi","sequence":"first","affiliation":[{"name":"Institute of Education and Research and Molecular Oncology Center, Barretos Cancer Hospital Pio XII Foundation Barretos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Humberto T.","family":"Fregnani","sequence":"additional","affiliation":[{"name":"Institute of Education and Research and Molecular Oncology Center, Department of Researcher Support, Barretos Cancer Hospital Pio XII Foundation Barretos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falio C\u00e9sar","family":"Possati\u2010Resende","sequence":"additional","affiliation":[{"name":"Institute of Education and Research and Molecular Oncology Center, Department of Prevention, Barretos Cancer Hospital Pio XII Foundation Barretos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio","family":"Antoniazzi","sequence":"additional","affiliation":[{"name":"Institute of Education and Research and Molecular Oncology Center, Department of Prevention, Barretos Cancer Hospital Pio XII Foundation Barretos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristovam","family":"Scapulatempo\u2010Neto","sequence":"additional","affiliation":[{"name":"Institute of Education and Research and Molecular Oncology Center, Department of Pathology, Barretos Cancer Hospital Pio XII Foundation Barretos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stina","family":"Syrj\u00e4nen","sequence":"additional","affiliation":[{"name":"Medicity Research Laboratory and Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine University of Turku Turku Finland"},{"name":"Department of Pathology Turku University Central Hospital Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa L.","family":"Villa","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences of Santa Casa of S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Radiology and Oncology, Faculty of Medicine Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adhemar","family":"Longatto\u2010Filho","sequence":"additional","affiliation":[{"name":"Institute of Education and Research and Molecular Oncology Center, Barretos Cancer Hospital Pio XII Foundation Barretos S\u00e3o Paulo Brazil"},{"name":"Laboratory of Medical Investigation 14, Faculty of Medicine Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Life and Health Sciences Research Institute, School of Health Sciences University of Minho Braga Portugal"},{"name":"Life and Health Sciences Research Institute\/3Bs\u2010PT Government Associate Laboratory Braga Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,12]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization and International Agency for Research on Cancer.Cervical cancer\u2010estimated incidence mortality and prevalence worldwide in 2012.http:\/\/globocan.iarc.fr\/Pages\/fact_sheets_cancer.aspx. Accessed January 20 2015."},{"key":"e_1_2_8_3_1","unstructured":"Instituto Nacional do Cancer\/National Cancer Institute (INCA).Cancer in Brazil: data from population\u2010based records [in Portuguese].http:\/\/www.inca.gov.br\/estimativa\/2016\/."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.07.055"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.083"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2012.01.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27828"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.095"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.18.7951"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21139"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02116-14"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.8389"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2014.03.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70210-9"},{"key":"e_1_2_8_15_1","volume-title":"The careHPV Test Training Guide","author":"Qiagen","year":"2008"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-12-201206190-00424"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.071"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000088"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu159"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.07.092"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.04.105"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28616"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-13-0091"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.09.018"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03432-13"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23972"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.033"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102002000100015"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102010000500023"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70158-5"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.12.004"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e318285437b"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e3182854253"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.08.005"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.044347"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2015-205851"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr532"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071430"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21463"},{"key":"e_1_2_8_40_1","volume-title":"Comprehensive Cervical Cancer Control\u2010A Guide to Essential Practice","author":"World Health Organization","year":"2014"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.1059"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.5533\/2177-8264-201123103"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1517-83822014005000047"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20700"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0173"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2012.09.022"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2013.02.003"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2007.09.001"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.11.014"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808516"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.12.033"}],"container-title":["Cancer Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncy.21718","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.21718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T09:57:59Z","timestamp":1760263079000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncy.21718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,12]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1002\/cncy.21718"],"URL":"https:\/\/doi.org\/10.1002\/cncy.21718","archive":["Portico"],"relation":{},"ISSN":["1934-662X","1934-6638"],"issn-type":[{"value":"1934-662X","type":"print"},{"value":"1934-6638","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,12]]}}}