{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:42:49Z","timestamp":1791229369270,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T00:00:00Z","timestamp":1461628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The interpretation of atypical glandular cells (AGC) in Papanicolaou (Pap) tests and screening for glandular neoplasia remain challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Pap tests with an AGC interpretation from January 2008 to December 2013 were retrieved from a pathology database, and cases with histologic follow\u2010up within 1 year were included in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>There were 589,830 Pap tests during the study period, and 3709 cases (0.6%) were reported as AGC, which included the following: AGC, not otherwise specified (52.0%); atypical endocervical cells (28.0%); and other categories. There were 3007 cases (81.1%) with histologic follow\u2010up results within 1 year. Cervical intraepithelial neoplasia 2\/3 (CIN2\/3), cervical adenocarcinoma in situ (AIS)\/adenocarcinoma, and endometrial carcinoma were identified in 5.6%, 1.9%, and 5.5% of cases, respectively. Glandular neoplasia was more likely to be identified in cases with pure AGC subcategories than cases with AGC and squamous abnormalities. Endometrial neoplasia was more likely to be identified in cases with atypical endometrial cells than other categories. Overall, the most common severe abnormality on histologic follow\u2010up was CIN2\/3. Although CIN2\/3 was the most common severe lesion in patients younger than 30 years (10.0%) and in patients aged 30 to 49 years (6.4%), endometrial carcinoma was the most common lesion in women who were 50 years old or older (13.7%). Endocervical glandular lesions (AIS and adenocarcinoma) occurred in only 1.9% of women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      AGC subtypes and ages significantly affect histological follow\u2010up results; 90.5% of cases with carcinoma on histologic follow\u2010up were either endometrial or metastatic carcinoma. This study supports the recommendation that women with AGC Pap test results should be followed up with both endocervical and endometrial sampling.\n                      <jats:bold>\n                        <jats:italic>Cancer Cytopathol<\/jats:italic>\n                        2016;124:589\u201095\n                      <\/jats:bold>\n                      . \u00a9\n                      <jats:italic>2016 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncy.21724","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T07:50:24Z","timestamp":1461743424000},"page":"589-595","source":"Crossref","is-referenced-by-count":64,"title":["Clinical significance of atypical glandular cells in Pap tests: An analysis of more than 3000 cases at a large academic women's center"],"prefix":"10.1002","volume":"124","author":[{"given":"Dinesh","family":"Pradhan","sequence":"first","affiliation":[{"name":"Department of Pathology Magee\u2010Womens Hospital, University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaibo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Magee\u2010Womens Hospital, University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Ocque","sequence":"additional","affiliation":[{"name":"Department of Pathology Magee\u2010Womens Hospital, University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stell","family":"Patadji","sequence":"additional","affiliation":[{"name":"Department of Pathology Magee\u2010Womens Hospital, University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology Magee\u2010Womens Hospital, University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20589"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326498"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326427"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326428"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pgp.0000170067.73452.72"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11826"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1309\/HL0B-C7Y6-AC77-ND2U"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22423"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/110.5.653"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325117"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000202401.29145.68"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn099"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22357"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11835"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199301000-00005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.5858\/2004-128-1224-BIARRP"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10886"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20600"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325682"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010225)93:1<8::AID-CNCR9001>3.0.CO;2-K"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.09.001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000152350.10875.02"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)30136-0"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325598"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.4414\/smw.2007.11928","article-title":"Reclassification and analysis of clinical significance of atypical glandular cells on ThinPrep using Bethesda 2001: Geneva experience","volume":"137","author":"Kumar N","year":"2007","journal-title":"Swiss Med Wkly."},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i276"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2014-0633-OA"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/1742-6413.144686"},{"key":"e_1_2_8_30_1","first-page":"457","article-title":"Analyses of atypical glandular cells re\u2010defined by the 2006 Bethesda System: histologic outcomes and clinical implication of follow\u2010up management","volume":"34","author":"Ulker V","year":"2013","journal-title":"Eur J Gynaecol Oncol."},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02769.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181c799a3"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2120"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.047"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182883a34"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010225)93:1<1::AID-CNCR9000>3.0.CO;2-7"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21139"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqv085"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21343"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21368"},{"key":"e_1_2_8_41_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5858\/2008-0755-OAR1.1","article-title":"Clinical utility of adjunctive high\u2010risk human papillomavirus DNA testing in women with Papanicolaou test findings of atypical glandular cells","volume":"134","author":"Zhao C","year":"2010","journal-title":"Arch Pathol Lab Med."},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23639"}],"container-title":["Cancer Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncy.21724","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.21724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T09:57:54Z","timestamp":1760263074000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncy.21724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,26]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1002\/cncy.21724"],"URL":"https:\/\/doi.org\/10.1002\/cncy.21724","archive":["Portico"],"relation":{},"ISSN":["1934-662X","1934-6638"],"issn-type":[{"value":"1934-662X","type":"print"},{"value":"1934-6638","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,26]]}}}