{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:02:59Z","timestamp":1791302579813,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T00:00:00Z","timestamp":1463097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["568971"],"award-info":[{"award-number":["568971"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Cancer Council NSW Strategic Research Partnership Program","award":["13-11"],"award-info":[{"award-number":["13-11"]}]},{"DOI":"10.13039\/501100001773","name":"University of New South Wales","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001773","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>In a cytology\u2010based screening program intended to prevent anal cancer, the anal transformation zone (TZ) should be adequately sampled because it is the site most susceptible to the development of the cancer precursor, high\u2010grade squamous intraepithelial lesion (HSIL). An adequate TZ component is defined as comprising at least 10 rectal columnar or squamous metaplastic cells. In the current study, the authors examined whether the presence of a TZ component in anal cytology correlated with the detection of histological HSIL.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>In a natural history study of anal human papillomavirus infection in homosexual men, all participants underwent liquid\u2010based cytology and high\u2010resolution anoscopy (HRA) with or without biopsy at each visit. True\u2010negative cytology (negative cytology with non\u2010HSIL biopsy or negative HRA), false\u2010negative cytology (negative cytology with HSIL biopsy), and true\u2010positive cytology (abnormal cytology with HSIL biopsy) were compared with regard to the presence or absence of a TZ component.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of 617 participants, baseline results included 155 true\u2010positive results, 191 true\u2010negative results, and 31 false\u2010negative results. The absence of an adequate TZ component was found to be significantly higher for false\u2010negative (32.3%) than for either true\u2010positive (11.0%; <jats:italic>P<\/jats:italic> = .0034) or true\u2010negative (13.1%; <jats:italic>P<\/jats:italic> = .0089) results.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Significantly more false\u2010negative cases lacked a TZ component compared with either true\u2010positive or true\u2010negative cases. TZ cells may be an important indicator of sample quality for anal cytology because, unlike cervical sampling, the anal canal is not visualized during cytology sampling. <jats:bold><jats:italic>Cancer Cytopathol<\/jats:italic> 2016;124:596\u2010601<\/jats:bold>. \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21730","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T10:52:40Z","timestamp":1463136760000},"page":"596-601","source":"Crossref","is-referenced-by-count":16,"title":["The value of a transformation zone component in anal cytology to detect HSIL"],"prefix":"10.1002","volume":"124","author":[{"given":"Jennifer M.","family":"Roberts","sequence":"first","affiliation":[{"name":"Cytology Department Douglass Hanly Moir Pathology Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyi","family":"Jin","sequence":"additional","affiliation":[{"name":"The Kirby Institute University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia K.","family":"Thurloe","sequence":"additional","affiliation":[{"name":"Cytology Department Douglass Hanly Moir Pathology Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Ekman","sequence":"additional","affiliation":[{"name":"Cytology Department Douglass Hanly Moir Pathology Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie K.","family":"Adams","sequence":"additional","affiliation":[{"name":"Cytology Department Douglass Hanly Moir Pathology Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross L.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Cytology Department Douglass Hanly Moir Pathology Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Biro","sequence":"additional","affiliation":[{"name":"Cytology Department Douglass Hanly Moir Pathology Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Mary","family":"Poynten","sequence":"additional","affiliation":[{"name":"The Kirby Institute University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E.","family":"Grulich","sequence":"additional","affiliation":[{"name":"The Kirby Institute University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"Farnsworth","sequence":"additional","affiliation":[{"name":"Cytology Department Douglass Hanly Moir Pathology Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of The Study of the Prevention of Anal Cancer (SPANC) Study Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1071\/SH12070"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20110"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462413481527"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20126"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-2042-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-11074-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-946"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-2042-8_8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.LGT200570"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21702"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e31819793d9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328333ab8e"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328339e592"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328359f255"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24188"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)02353-3"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990625)87:3<113::AID-CNCR3>3.0.CO;2-V"},{"key":"e_1_2_8_19_1","first-page":"323","article-title":"Relationship between the diagnosis of epithelial abnormalities and the composition of cervical smears","volume":"29","author":"Vooijs PG","year":"1985","journal-title":"Acta Cytol."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)01998-1"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1309\/RP84-MD34-8MFN-39UR"},{"key":"e_1_2_8_22_1","first-page":"258","article-title":"Papanicolaou smears without endocervical cells. 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