{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:48:40Z","timestamp":1782773320897,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T00:00:00Z","timestamp":1470787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>\u201cThe Paris System\u201d proposes a 7\u2010tier classification system for urine cytology. Establishing the risk of malignancy (ROM) associated with these diagnostic categories is essential to determine the appropriate management of patients. The objective of this study was to determine the ROM associated with the \u201cpositive\u201d and \u201csuspicious\u201d categories.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors searched their electronic records for urine cytology specimens that had been diagnosed as \u201cpositive\u201d or \u201csuspicious\u201d for high\u2010grade urothelial carcinoma within an 11\u2010year time frame. Then, the ROM was determined for these specimens within a 6\u2010month follow\u2010up interval. The cytologic diagnoses were correlated with surgical biopsy results, follow\u2010up cytology results, and\/or fluorescence in situ hybridization (FISH) results.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In total, 662 specimens (487 \u201cpositive\u201d and 175 \u201csuspicious\u201d), corresponding to 387 patients (295 men and 92 women), were included. The majority of specimens were collected by bladder washing (568 of 662 specimens; 85.4%) and for the indication of surveillance (601 of 662 specimens; 82%). On follow\u2010up, bladder washing specimens were positive more often positive than voided urine specimens (466 of 570 [81.8%] vs 60 of 92 [65.2%]; <jats:italic>P<\/jats:italic>\u2009=\u2009.0005), and surveillance specimens were more often positive than specimens collected for other indications (82% vs 54.1%). The overall positive predictive value was higher for positive specimens than for suspicious specimens (365 of 461 [79.2%] vs 83 of 150 [55.3%]; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Diagnoses of suspicious for high\u2010grade urothelial carcinoma, as used at the authors' institution, have an ROM that is high but is lower than that for the \u201cpositive\u201d category. Therefore, the authors suggest keeping the 2 categories separate, although management should be aggressive in both groups. <jats:bold><jats:italic>Cancer Cytopathol<\/jats:italic> 2016;124:811\u20109<\/jats:bold>. \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21764","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T09:26:41Z","timestamp":1470821201000},"page":"811-819","source":"Crossref","is-referenced-by-count":32,"title":["The positive predictive value of \u201csuspicious for high\u2010grade urothelial carcinoma\u201d in urinary tract cytology specimens: A single\u2010institution study of 665 cases"],"prefix":"10.1002","volume":"124","author":[{"given":"Anthony M.","family":"Joudi","sequence":"first","affiliation":[{"name":"Department of Pathology Loyola University Medical Center Maywood Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan E.","family":"Pambuccian","sequence":"additional","affiliation":[{"name":"Department of Pathology Loyola University Medical Center Maywood Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M.","family":"Wojcik","sequence":"additional","affiliation":[{"name":"Department of Pathology Loyola University Medical Center Maywood Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcliz A.","family":"Barkan","sequence":"additional","affiliation":[{"name":"Department of Pathology Loyola University Medical Center Maywood 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