{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:09:37Z","timestamp":1765609777231,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T00:00:00Z","timestamp":1494547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA016672"],"award-info":[{"award-number":["P30 CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Papanicolaou (Pap) cytology and high\u2010risk human papillomavirus (HPV) DNA cotesting for women aged \u226530 years are recommended for the prevention of cervical cancer. The objective of the current study was to evaluate the efficacy of this cotesting for predicting the risk of high\u2010grade cervical intraepithelial neoplasia 3 (CIN3) during a 3\u2010year follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A retrospective database search identified women aged \u226530 years who had baseline HPV and Pap cytology cotesting results in 2007 or 2008 and for whom 3\u2010year follow\u2010up results were available. The cumulative 3\u2010year risks of developing CIN\u20103 were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The 3\u2010year follow\u2010up data after baseline Pap\/HPV cotesting were available for 1986 women (mean age, 53 years). Of the 1668 women who had a baseline Pap\u2010negative (Pap\u2010)\/HPV\u2010 cotesting result, 1561 (93.6%) had a follow\u2010up Pap cytology result that was negative for intraepithelial lesions or malignancy. Of the 1530 women who had follow\u2010up Pap\/HPV cotesting, 1504 (98.3%) had a Pap\u2010\/HPV\u2010 result. The 3\u2010year cumulative risk of developing CIN\u20103 was found to be highest for women with a baseline Pap\u2010positive (Pap+)\/HPV+ cotesting result (12.5%); the risk of CIN\u20103 was lower in those with a Pap\u2010\/HPV+ result (1.5%; <jats:italic>P<\/jats:italic> = .0032) or a Pap\u2010\/HPV\u2010 result (0.06%; <jats:italic>P<\/jats:italic>&lt;.0001). The 3\u2010year cumulative risk of CIN\u20103 was found to be significantly greater for women with an HPV+ result (4.8%) compared with those with an HPV\u2010 result (0.06%; <jats:italic>P<\/jats:italic>&lt;.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Pap cytology and HPV cotesting are valuable for stratifying CIN\u20103 risk. Pap cytology and HPV co\u2010screening at a 3\u2010year screening interval appears to carry a low risk of CIN\u20103 for women who have a baseline Pap\u2010\/HPV\u2010 cotesting result. <jats:bold><jats:italic>Cancer Cytopathol<\/jats:italic> 2017;125:644\u201051<\/jats:bold>. \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21877","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T10:17:01Z","timestamp":1494584221000},"page":"644-651","source":"Crossref","is-referenced-by-count":9,"title":["Three\u2010year risk of high\u2010grade CIN for women aged 30 years or older who undergo baseline Pap cytology and HPV co\u2010screening"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-1145","authenticated-orcid":false,"given":"Ming","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abha","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn A.","family":"Dawlett","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa L.","family":"Kologinczak","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevieve R.","family":"Lyons","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Roland L.","family":"Bassett","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nour","family":"Sneige","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese B.","family":"Bevers","sequence":"additional","affiliation":[{"name":"Cancer Prevention Center The University of Texas MD Anderson Cancer Center Houston 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