{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T14:19:33Z","timestamp":1771078773977,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T00:00:00Z","timestamp":1502928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The objective of this study was to compare cervical high\u2010grade squamous intraepithelial lesions subcategorized as cervical intraepithelial neoplasia\u20103 (CIN\u20103)\u2013positive after a negative cytology result but positive for high\u2010risk human papillomavirus (HR\u2010HPV) testing to those with a negative HR\u2010HPV test but positive cytology (atypical squamous cells of undetermined significance [ASCUS]\u2010positive\/HPV\u2010negative) and to assess reasons for discrepancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors retrospectively analyzed women who underwent screening with cytology and HPV testing from 2010 through 2013. After a review of surgical specimens and cytology, discrepancies were classified as sampling or interpretation error. Clinical and pathologic findings were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In total, 15,173 women (age range, 25\u201095 years; 7.1% were aged\u2009&lt;\u200930 years) underwent both HPV and cytologic testing, and 1184 (8.4%) underwent biopsy. Cytology was positive in 19.4% of specimens, and HPV was positive in 14.5%. Eighty\u2010four CIN\u20103\u2013positive specimens were detected, including 55 that tested ASCUS\u2010positive\/HPV\u2010positive, 11 that tested negative for intraepithelial lesion or malignancy (NILM)\/HPV\u2010positive, 10 that tested ASCUS\u2010positive\/HPV\u2010negative, 3 that tested NILM\/HPV\u2010negative, and 5 tests that were unsatisfactory. There was no significant difference between NILM\/HPV\u2010positive and ASCUS\u2010positive\/HPV\u2010negative CIN\u20103 in terms of size, time to occurrence, the presence of a cytopathic effect, screening history, race, or age. Six of 11 NILM\/HPV\u2010positive cases were reclassified as ASCUS, indicating an interpreting error of 55% and a sampling error of 45%. No ASCUS\u2010positive\/HPV\u2010negative cases were reclassified. Seven cases of CIN\u20103 with positive cytology were HPV\u2010negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>There are no significant clinical or pathologic differences between NILM\/HPV\u2010positive and ASCUS\u2010positive\/HPV\u2010negative CIN\u20103\u2013positive specimens. Cytologic sampling or interpretation remains the main reason for discrepancies. However, HPV\u2010negative CIN\u20103 with positive cytology exists and may be missed by primary HPV screening. <jats:bold><jats:italic>Cancer Cytopathol<\/jats:italic> 2017;125:795\u2010805<\/jats:bold>. \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21905","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T10:46:44Z","timestamp":1502966804000},"page":"795-805","source":"Crossref","is-referenced-by-count":10,"title":["Discrepant HPV\/cytology cotesting results: Are there differences between cytology\u2010negative versus HPV\u2010negative cervical intraepithelial neoplasia?"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2886-0267","authenticated-orcid":false,"given":"Jessica M.","family":"Tracht","sequence":"first","affiliation":[{"name":"Department of Pathology the University of Alabama at Birmingham School of Medicine Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoinette D.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Pathology the University of Alabama at Birmingham School of Medicine Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle N.","family":"Fasciano","sequence":"additional","affiliation":[{"name":"Department of Pathology the University of Alabama at Birmingham School of Medicine Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isam\u2010Eldin A.","family":"Eltoum","sequence":"additional","affiliation":[{"name":"Department of Pathology the University of Alabama at Birmingham School of Medicine Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21139"},{"key":"e_1_2_8_3_1","first-page":"853","article-title":"Human papilloma virus infection and cervical dysplasia","volume":"116","author":"Melinte\u2010Popescu A","year":"2012","journal-title":"Rev Med Chir Soc Med Nat Iasi"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009584"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.07.024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23726"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.439"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.11.076"},{"key":"e_1_2_8_10_1","unstructured":"US Food and Drug Administration (FDA). 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