{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:07:40Z","timestamp":1785557260242,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Digital pathology increasingly has been gaining the attention of pathologists worldwide. However, the application of digital cytology by Panoptiq (ViewsIQ, Vancouver, Canada) microscope\u2010based scanning software is relatively unexplored. Panoptiq enables the operator to combine low\u2010power panoramic digital images with z\u2010stacks at regions of interest with a significantly smaller image size than that obtained by whole\u2010slide scanning. The current study aimed to evaluate the feasibility of the use of Panoptiq in the digital interpretation of cervicovaginal cytology specimens in comparison with conventional light microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 100 liquid\u2010based cytology slides were selected sequentially. The dotted slides were reviewed and scanned, in which all dotted areas were scanned further by the \u00d720 objective with z\u2010stacks. The cases were reviewed by 4 pathologists and a cytotechnologist using conventional light microscopy and digital cytology images acquired by Panoptiq and interpreted based on the Bethesda classification system. The washout time was set as 3 weeks. The Cohen kappa coefficient was calculated to measure the agreement between the 2 modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Digital cytology demonstrated an intermodality agreement among 3 observers who had sufficient training in digital pathology at concordance rates between 81% and 90% with kappa values between 0.76 and 0.86, whereas the other 2 observers who did not have sufficient training in digital pathology had lower agreement at a concordance rate of between 56% and 57%, with kappa values between 0.41 and 0.44.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Panoptiq appears to be feasible for the interpretation of cervicovaginal cytology specimens but requires adequate training in digital pathology. <jats:bold><jats:italic>Cancer Cytopathol<\/jats:italic> 2017;125:918\u201025.<\/jats:bold> \u00a9 <jats:italic>2017 American Cancer Society.<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21921","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T12:22:15Z","timestamp":1506601335000},"page":"918-925","source":"Crossref","is-referenced-by-count":14,"title":["Application of microscope\u2010based scanning software (Panoptiq) for the interpretation of cervicovaginal cytology specimens"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6431-6819","authenticated-orcid":false,"given":"Ruben","family":"Groen","sequence":"first","affiliation":[{"name":"Nagasaki Educational and Diagnostic Center of Pathology Nagasaki University Hospital Nagasaki Japan"},{"name":"Department of Pathology Kameda Medical Center Kamogawa Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniko","family":"Abe","sequence":"additional","affiliation":[{"name":"Nagasaki Educational and Diagnostic Center of Pathology Nagasaki University Hospital Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Seung","family":"Yoon","sequence":"additional","affiliation":[{"name":"Nagasaki Educational and Diagnostic Center of Pathology Nagasaki University Hospital Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaibo","family":"Li","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rulong","family":"Shen","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Nagasaki Educational and Diagnostic Center of Pathology Nagasaki University Hospital Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Nitanda","sequence":"additional","affiliation":[{"name":"Nagasaki Educational and Diagnostic Center of Pathology Nagasaki University Hospital Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kameda Medical Center Kamogawa Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Pathology Kameda Medical Center Kamogawa Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Fukuoka","sequence":"additional","affiliation":[{"name":"Nagasaki Educational and Diagnostic Center of Pathology Nagasaki University Hospital Nagasaki Japan"},{"name":"Department of Pathology Kameda Medical Center Kamogawa Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324734"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/2153-3539.181770"},{"key":"e_1_2_8_4_1","unstructured":"RhoadsDD AhmedI PantanowitzL. Feasibility of using the Panoptiq imaging system for telemicrobiology. Poster presented at: Pathology Informatics Summit 2015; May 6 2015; Pittsburgh PA.Wyndham Grand Pittsburgh Hotel May 5\u20138 2015 Ballroom 1 King's Garden 1 King's Garden 2\/3 Brigade Roomhttp:\/\/www.jpathinformatics.org\/temp\/JPatholInform6124-4776798_131607.pdf."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12294"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21880"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802123380703"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1309\/J6JM-2741-HM34-1F1E"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970225)81:1<10::AID-CNCR4>3.0.CO;2-K"},{"key":"e_1_2_8_11_1","first-page":"794","article-title":"Intraobserver and interobserver variability in the diagnosis of epithelial abnormalities in cervical smears","volume":"32","author":"Klinkhamer PJ","year":"1988","journal-title":"Acta Cytol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840110408"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/105.5.599"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.29651"},{"key":"e_1_2_8_15_1","first-page":"646","article-title":"Telepathology and the networking of pathology diagnostic services","volume":"111","author":"Weinstein RS","year":"1987","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2004.00147.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/264683"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/2153-3539.115874"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2010.00774.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0093-CP"}],"container-title":["Cancer Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncy.21921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.21921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T14:22:23Z","timestamp":1760278943000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncy.21921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,28]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/cncy.21921"],"URL":"https:\/\/doi.org\/10.1002\/cncy.21921","archive":["Portico"],"relation":{},"ISSN":["1934-662X","1934-6638"],"issn-type":[{"value":"1934-662X","type":"print"},{"value":"1934-6638","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,28]]}}}