{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:11:36Z","timestamp":1790140296614,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T00:00:00Z","timestamp":1508457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["568971"],"award-info":[{"award-number":["568971"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Longitudinal studies of histological outcomes after anal cytological screening in men who have sex with men (MSM) are rare. This study measured the positive predictive values (PPVs) of each level of baseline cytological abnormality in MSM in Sydney, Australia, over a 12\u2010month period.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The Study of the Prevention of Anal Cancer is a 3\u2010year prospective study of the natural history of anal human papillomavirus infection in MSM at least 35 years old. For each participant with a baseline cytological abnormality, the worst histology was recorded at the baseline high\u2010resolution anoscopy and at 6 and 12 months. PPVs for a histological high\u2010grade squamous intraepithelial lesion (HSIL) diagnosis were calculated for each level of baseline cytological abnormality at each time point.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Among 424 men who completed 3 visits, the PPV of a cytological HSIL increased from 71.6% at the baseline to 86.4% at 6 months and to 92.6% at 12 months (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). For cytological atypical squamous cells, cannot rule out high\u2010grade squamous intraepithelial lesion (ASC\u2010H), the PPV increased from 51.5% at the baseline to 69.7% at 6 months and to 75.8% at 12 months (<jats:italic>P<\/jats:italic>\u2009=\u2009.004). At each time point, the PPV of a cytological HSIL was significantly higher than the PPV of ASC\u2010H. The PPV of low\u2010grade cytology reports was significantly lower than the PPV of ASC\u2010H at each time point.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In a cohort of MSM, a baseline histological HSIL diagnosis after an HSIL cytoprediction is high, and it increases with further examinations over the course of 12 months. Lower levels of cytological abnormalities have significantly lower PPVs. These data can inform patient management and the quality assessment of each aspect of the screening pathway. <jats:bold><jats:italic>Cancer Cytopathol<\/jats:italic> 2018;126:136\u201044.<\/jats:bold> \u00a9 <jats:italic>2017 American Cancer Society.<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21936","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T09:30:05Z","timestamp":1508491805000},"page":"136-144","source":"Crossref","is-referenced-by-count":14,"title":["Histological outcomes of anal high\u2010grade cytopredictions"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7229-8617","authenticated-orcid":false,"given":"Jennifer Margaret","family":"Roberts","sequence":"first","affiliation":[{"name":"Cytopathology Department, Douglass Hanly Moir Pathology Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyi","family":"Jin","sequence":"additional","affiliation":[{"name":"Kirby Institute, University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isobel Mary","family":"Poynten","sequence":"additional","affiliation":[{"name":"Kirby Institute, University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmella","family":"Law","sequence":"additional","affiliation":[{"name":"St Vincent's Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David James","family":"Templeton","sequence":"additional","affiliation":[{"name":"Kirby Institute, University of New South Wales Sydney New South Wales Australia"},{"name":"RPA Sexual Health, Sydney Local Health District and Central Clinical School, University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Kathleen","family":"Thurloe","sequence":"additional","affiliation":[{"name":"Cytopathology Department, Douglass Hanly Moir Pathology Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne Marie","family":"Garland","sequence":"additional","affiliation":[{"name":"Regional HPV LabNet Reference Laboratory, Department of Microbiology and Infectious Diseases Royal Women's Hospital Parkville Victoria Australia"},{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Edwin","family":"Grulich","sequence":"additional","affiliation":[{"name":"Kirby Institute, University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"Farnsworth","sequence":"additional","affiliation":[{"name":"Cytopathology Department, Douglass Hanly Moir Pathology Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard John","family":"Hillman","sequence":"additional","affiliation":[{"name":"Kirby Institute, University of New South Wales Sydney New South Wales Australia"},{"name":"Dysplasia and Anal Cancer Services, HIV, Immunology, and Infectious Diseases, St Vincent's Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Study of the Prevention of Anal Cancer Study 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