{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:08:40Z","timestamp":1793066920129,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T00:00:00Z","timestamp":1510531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Fine\u2010needle aspiration (FNA) is routinely performed to evaluate salivary gland lesions, and provides valuable information regarding the cytomorphologic features of the lesions. Occasionally, there are overlaps between benign and malignant conditions due to heterogeneity of the cell types, metaplastic changes, and sampling issues. Herein, the authors present a retrospective study of diagnostic pitfalls in salivary gland cytology and the simulating conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A 20\u2010year retrospective review (1995\u20102015) of medical records was performed searching for the cytology reports of patients who underwent FNA of the salivary gland with the words \u201camendment\u201d or \u201crevision.\u201d Medical records of the revised cases were reviewed for the subsequent surgical follow\u2010up. All cases with a diagnostic discrepancy between the primary cytologic diagnosis and the final histology diagnosis were included in the current study. The histologic diagnosis was considered the gold standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 19 cases were included in the current study. The cases were divided into 7 categories based on their cytologic diagnoses: 1) nondiagnostic (1 case); 2) benign, nonneoplastic lesion (2 cases); 3) benign salivary gland neoplasm (2 cases); 4) salivary gland neoplasm (4 cases); 5) epithelial neoplasm, not otherwise specified (1 case); 6) markedly atypical cells suspicious for a malignant neoplasm (1 case); and 7) malignant neoplasms (8 cases).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The interpretation of salivary gland FNA can be influenced by several factors including prominent metaplasia, focal atypia, cystic changes, variable cellular components within the lesions, scant cellularity, variants of neoplasms, and a prior history of malignancy. Multiple passes representing the entire mass, imaging findings, and familiarity with salivary gland cytomorphology may improve the diagnostic accuracy. <jats:bold><jats:italic>Cancer Cytopathol<\/jats:italic> 2018;126:101\u201011.<\/jats:bold> \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21949","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T11:46:19Z","timestamp":1510573579000},"page":"101-111","source":"Crossref","is-referenced-by-count":51,"title":["Diagnostic challenges and problem cases in salivary gland cytology: A 20\u2010year experience"],"prefix":"10.1002","volume":"126","author":[{"given":"Sajad","family":"Salehi","sequence":"first","affiliation":[{"name":"Department of Pathology St. John Hospital and Medical Center Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3273-4802","authenticated-orcid":false,"given":"Zahra","family":"Maleki","sequence":"additional","affiliation":[{"name":"Division of Cytopathology, Pathology Department The Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(20000301)22:3<139::AID-DC2>3.0.CO;2-A"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-3154-0.00005-3"},{"issue":"2","key":"e_1_2_8_4_1","first-page":"213","article-title":"Fine\u2010needle aspiration biopsy of the salivary glands","volume":"27","author":"Cohen MB","year":"1992","journal-title":"Pathol Annu."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588413X13511609958370"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840070311"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199906)20:6<358::AID-DC6>3.0.CO;2-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0222-RA"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23715"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5858\/2005-129-26-PISGFC"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/B978-1-4557-4462-6.00011-8","volume-title":"Cytology: Diagnostic Principles and Clinical Correlates","author":"Krane JF","year":"2014"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871001)60:7<1589::AID-CNCR2820600729>3.0.CO;2-U"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23551"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20430"},{"key":"e_1_2_8_15_1","volume-title":"Cytology: Diagnostic Principles and Clinical Correlates","author":"Cibas ES","year":"2014"},{"key":"e_1_2_8_16_1","first-page":"346","article-title":"Fine\u2010needle aspiration of salivary gland lesions. 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