{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:59:11Z","timestamp":1780498751875,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The recent revision in terminology, with <jats:italic>noninvasive follicular thyroid neoplasm with papillary\u2010like nuclear features<\/jats:italic> (NIFTP) replacing <jats:italic>noninvasive follicular variant of papillary thyroid carcinoma<\/jats:italic>, has reclassified the clinically indolent tumor as nonmalignant. The objective of this study was to evaluate the impact of this change on the rate of malignancy (ROM) for subcategories of an atypia of undetermined significance (AUS) diagnosis on fine\u2010needle aspiration (FNA) cytology.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Consecutive thyroid FNAs interpreted as AUS over a period of 4 years were retrospectively analyzed. The ROM for AUS subcategories, including atypia of undetermined significance with nuclear atypia (AUS\u2010N), atypia of undetermined significance with a microfollicular pattern (AUS\u2010F), atypia of undetermined significance with nuclear atypia and a microfollicular pattern (AUS\u2010N\/F), atypia of undetermined significance with H\u00fcrthle cells (AUS\u2010H), and atypia of undetermined significance, not otherwise specified (AUS\u2010NOS), were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of the 426 nodules interpreted as AUS, 244 were surgically excised. The incidence of NIFTP in each subcategory was as follows: 18% for AUS\u2010N, 18% for AUS\u2010F, 9% for AUS\u2010N\/F, 3% for AUS\u2010H, and 0% for AUS\u2010NOS. After the reclassification of NIFTP as nonmalignant, the ROM based on histologic follow\u2010up significantly decreased from 43% to 26% for AUS\u2010N (<jats:italic>P<\/jats:italic> &lt; .001) and from 29% to 10% for AUS\u2010F (<jats:italic>P<\/jats:italic> = .008). The ROM for AUS\u2010N remained significantly higher than the ROM for AUS\u2010F (<jats:italic>P<\/jats:italic> = .030).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>A subset of resected AUS nodules can be reclassified as NIFTP, and that significantly decreases the ROM, especially for AUS\u2010N and AUS\u2010F. Nonetheless, AUS\u2010N still harbors a substantially higher ROM than AUS\u2010F. <jats:bold><jats:italic>Cancer Cytopathol<\/jats:italic> 2018;126:309\u201016.<\/jats:bold> \u00a9 <jats:italic>2018 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21981","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T10:10:33Z","timestamp":1518171033000},"page":"309-316","source":"Crossref","is-referenced-by-count":14,"title":["The impact of noninvasive follicular thyroid neoplasm with papillary\u2010like nuclear features on the rate of malignancy for atypia of undetermined significance subcategories"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-2784","authenticated-orcid":false,"given":"Jen\u2010Fan","family":"Hang","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Pathology The Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Westra","sequence":"additional","affiliation":[{"name":"Department of Pathology The Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2608-2388","authenticated-orcid":false,"given":"Amy G.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology The Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism The Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Z.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pathology The Johns Hopkins Hospital Baltimore Maryland"},{"name":"Department of Radiology The Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-87666-5_4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP5N4MTHPAFXFB"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21754"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339959"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20029"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0108"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0154-SA"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20091"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333232"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPIX52MBOKTICP"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPO0BQ2YSKPXXP"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21790"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21411"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23052"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21396"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23472"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21827"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21823"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-017-9486-3"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12352"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0221"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21412"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0500"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0100-RA"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0386"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21631"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0612"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21879"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000469654"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21926"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.130"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1484-1"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0079"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203208"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0628"}],"container-title":["Cancer 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