{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:58:00Z","timestamp":1789577880602,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study was to examine the prevalence of human papillomavirus 16\/18 (HPV\u201016\/18) genotypes and immediate histopathologic correlations in a Chinese population with negative cytology and positive high\u2010risk human papillomavirus (hrHPV) testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who had documented negative cytology with immediate follow\u2010up (within the 6 months after negative for intraepithelial lesion or malignancy Papanicolaou [Pap] testing), including a histopathologic examination and\/or hrHPV testing, between 2011 and 2018 were included, and the data were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1,424,182 Pap tests, 1,333,453 (93.6%) were interpreted as negative cytology. Although conventional Pap smears had the highest reporting rate, cervical intraepithelial neoplasia 2 and higher (CIN\u20102+) lesions were detected significantly more with liquid\u2010based cytology preparations (2.1%) than the conventional method (1.4%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). The overall hrHPV\u2010positive rate was 14.9% (25,507 of 171,273) in the women with negative cytology. Among the 18,423 cytology\u2010negative, HPV\u2010positive cases tested with the Cobas assay, the overall HPV\u201016\/18 prevalence was 24.7%, with 17.9% being HPV\u201016\u2013positive, 6.2% being HPV\u201018\u2013positive, and 0.6% being positive for both HPV\u201016 and HPV\u201018. The immediate histopathologic examination was documented for 21,796 women with cotesting results, including 8915 HPV\u2010positive cases and 12,881 HPV\u2010negative cases. CIN\u20102+ lesions were diagnosed in 15.2% of the HPV\u201016\u2013positive cases; this rate was significantly higher than the rates seen in the HPV\u201018\u2013positive cases (4.8%) and the cases positive for 1 of the other 12 types of HPV (3.0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is by far the largest routine clinical practice report of HPV\u201016\/18 genotyping and histopathologic examination in negative\u2010cytology women and the first report of such an investigation in the Chinese population. This study indicates enhanced risk stratification with HPV\u201016\/18 genotype testing in HPV\u2010positive, cytology\u2010negative women in the Chinese population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22180","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T11:29:21Z","timestamp":1568806161000},"page":"650-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence of HPV\u201016\/18 genotypes and immediate histopathologic correlation results in a Chinese population with negative cytology and positive high\u2010risk HPV testing"],"prefix":"10.1002","volume":"127","author":[{"given":"Xiang","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Pathology Obstetrics and Gynecology Hospital of Fudan University  Shanghai 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