{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:59:23Z","timestamp":1791932363079,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sclerosing pneumocytoma (SP) is a rare, benign pulmonary neoplasm. To the authors' knowledge, the current study is the first to evaluate the cytomorphology and immunoprofile of SP in a series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 9 fine\u2010needle aspiration cases of SP (7 of which were computed tomography guided and 2 of which were endobronchial ultrasound guided) including histopathology and immunohistochemistry were collected from 5 institutions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The female\u2010to\u2010male ratio was 3.5:1, and the mean age of the patients was 54\u00a0years (range, 27\u201073\u00a0years). All cases presented as lung nodules, with a mean size of 2.2\u00a0cm (range, 1.1\u20105\u00a0cm), and were interpreted as atypical on rapid on\u2010site evaluation. The final diagnoses were favor adenocarcinoma (1 case), well\u2010differentiated lung adenocarcinoma (2 cases), low\u2010grade epithelial neoplasm (2 cases), and sclerosing pneumocytoma (4 cases). Samples were moderately cellular, and consisted of round epithelioid cells with clear cell features, columnar cells, and spindle cells. A papillary arrangement with prominent hyalinized fibrovascular cores was the most common architectural pattern, followed by flat sheets and acinar formations. Tumor cells demonstrated mild, focally moderate nuclear pleomorphism with prominent nucleoli, hyperchromasia, nuclear elongation, nuclear overlap, and occasional nuclear inclusions and grooves. The background consisted of foamy macrophages (9 cases), hemosiderin pigment (6 cases), and lymphoid aggregates (3 cases) with no mitoses and\/or necrosis. The surface cells and underlying round cells were positive for both thyroid transcription factor 1 and epithelial membrane antigen in all cases, which was the most notable immunohistochemical finding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cytomorphological findings of SP overlap with those of well\u2010differentiated lung adenocarcinoma. Awareness of these cytomorphologic findings and the distinct immunoprofile of the 2 cell types found in SP should prevent a misdiagnosis and aggressive treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22251","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T07:05:17Z","timestamp":1580886317000},"page":"414-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Pulmonary sclerosing pneumocytoma: Cytomorphology and immunoprofile"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3273-4802","authenticated-orcid":false,"given":"Zahra","family":"Maleki","sequence":"first","affiliation":[{"name":"Division of Cytopathology, Department of Pathology The Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Muller","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lester","family":"Layfield","sequence":"additional","affiliation":[{"name":"Department of Pathology and Anatomical Sciences University of Missouri School of Medicine Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1812-8729","authenticated-orcid":false,"given":"Momin T.","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine Department of Pathology New York Presbyterian\u2013Weill Cornell Medicine New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Rekhtman","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8182-5503","authenticated-orcid":false,"given":"Liron","family":"Pantanowitz","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198008000-00003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.05.069"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195601\/02)9:1<53::AID-CNCR2820090104>3.0.CO;2-U"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200007000-00002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00709988"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015038"},{"issue":"2","key":"e_1_2_8_8_1","article-title":"Sclerosing pneumocytoma: a ten\u2010year experience at a western Balkan university hospital","volume":"55","author":"Lovrenski A","year":"2019","journal-title":"Medicina (Kaunas)"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000498"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-005-0024-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-009-0452-y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22877"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23720"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"820","DOI":"10.5858\/133.5.820","article-title":"Sclerosing hemangioma of the lung","volume":"133","author":"Keylock JB","year":"2009","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/1742-6413.180783"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2004.19.3.352"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.5858\/2003-127-0321-PSHWLN"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2003.44.1.150"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2162"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198606000-00008"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-11-85"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0b013e3181ab3198"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-006-0339-6"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2009.07.002"},{"key":"e_1_2_8_25_1","first-page":"933","article-title":"Fine needle aspiration biopsy cytology of sclerosing hemangioma of the lung. 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