{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:25:50Z","timestamp":1789244750954,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:00:00Z","timestamp":1585872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Understanding racial influences on human papillomavirus (HPV) distribution in women with atypical squamous cells of undetermined significance (ASCUS) cytology via partial genotyping in a statewide population can inform HPV\u2010based prevention efforts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women aged 21 to 65\u00a0years with any cytology result and partial HPV genotyping for ASCUS triage between January 1, 2014, and December 31, 2017, were included. All women attended a Mississippi State Department of Health clinic. Age, race, cytopathologic, and HPV data were extracted from the electronic health record and analyzed. Cytologic specimens were processed with ThinPrep and HPV testing with the Cobas 4800 assay. HPV genotypes were evaluated in hierarchical categories. Chi\u2010square tests and multinomial logistic regression models evaluated associations between race and type prevalence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 43,106 women who underwent cervical cancer screening with cytology and ASCUS triage. Of these, 34,363 (80.2%) had normal cytology, 4672 (10.9%) had ASCUS, 2683 (6.3%) had a low\u2010grade squamous intraepithelial lesion, and 633 (1.5%) had a high\u2010grade squamous intraepithelial lesion. Blacks represented 69.3% of the sample and had a higher proportion of HPV\u2010positive ASCUS (6.5%) in comparison with whites (5.6%). Blacks had significantly decreased odds of HPV\u201016 (odds ratio [OR], 0.66; 95% confidence interval [CI], 0.6\u20100.9; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002) and significantly increased odds for 12 other types (OR, 1.37; 95% CI, 1.2\u20101.5; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) in comparison with whites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a diverse population, significant differences in HPV genotypes are shown by race. Importantly, blacks with ASCUS are less likely to be positive for HPV\u201016 in comparison with whites. Ongoing work is evaluating the individual genotype prevalence and genotype\u2010specific risk of precancer by race.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22267","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T16:29:26Z","timestamp":1585931366000},"page":"528-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Racial differences in HPV type 16 prevalence in women with ASCUS of the uterine cervix"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9434-0185","authenticated-orcid":false,"given":"Carolann","family":"Risley","sequence":"first","affiliation":[{"name":"School of Nursing University of Mississippi Medical Center Jackson Mississippi"},{"name":"National Cancer Institute Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan A.","family":"Clarke","sequence":"additional","affiliation":[{"name":"National Cancer Institute Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim R.","family":"Geisinger","sequence":"additional","affiliation":[{"name":"School of Nursing University of Mississippi Medical Center Jackson Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary W.","family":"Stewart","sequence":"additional","affiliation":[{"name":"School of Nursing University of Mississippi Medical Center Jackson Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Nursing University of Mississippi Medical Center Jackson Mississippi"},{"name":"Mississippi State Department of Health Jackson Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim W.","family":"Hoover","sequence":"additional","affiliation":[{"name":"School of Nursing University of Mississippi Medical Center Jackson Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laree M.","family":"Hiser","sequence":"additional","affiliation":[{"name":"School of Nursing University of Mississippi Medical Center Jackson Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenyata","family":"Owens","sequence":"additional","affiliation":[{"name":"School of Nursing University of Mississippi Medical Center Jackson Mississippi"},{"name":"Center for Informatics and Analytics University of Mississippi Medical Center Jackson Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"DeMarco","sequence":"additional","affiliation":[{"name":"National Cancer Institute Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Schiffman","sequence":"additional","affiliation":[{"name":"National Cancer Institute Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1251-0836","authenticated-orcid":false,"given":"Nicolas","family":"Wentzensen","sequence":"additional","affiliation":[{"name":"National Cancer Institute Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.86"},{"issue":"2","key":"e_1_2_8_3_1","first-page":"794","article-title":"Condylomata acuminata and human genital cancer","volume":"36","author":"zur Hausen H","year":"1976","journal-title":"Cancer Res"},{"key":"e_1_2_8_4_1","unstructured":"International Agency for Research on Cancer.Human Papillomaviruses. Published2007. Accessed December 28 2019.https:\/\/monographs.iarc.fr\/wp-content\/uploads\/2018\/06\/mono100B-11.pdf"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30716"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2017.08.015"},{"key":"e_1_2_8_7_1","volume-title":"Human Papillomavirus and Related Diseases in the World: Summary Report","author":"Bruni L","year":"2019"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034044"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv086"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-014-0406-2"},{"key":"e_1_2_8_11_1","unstructured":"Mississippi Cancer Registry.Cervical Mortality. Published2017. Accessed December 28 2019.https:\/\/www.umc.edu\/cancerinstitute\/Cancer-Research\/Cancer-Registries\/Mississippi%20Cancer%20Registry\/HOME-PAGE-CONTENT.html"},{"key":"e_1_2_8_12_1","volume-title":"Modern Cytopathology","author":"Geisinger KR","year":"2003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.5858\/2003-127-946-FTDFTA"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.11.015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21521"},{"key":"e_1_2_8_16_1","unstructured":"Roche.Cobas\u00ae 4800 System. Updated December 28 2019. Accessed December 28 2019.https:\/\/diagnostics.roche.com\/us\/en\/products\/systems\/cobas-4800-system.html"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001721"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-12-1406"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27485"},{"key":"e_1_2_8_20_1","volume-title":"Human Papillomavirus and Related Diseases in Africa: Summary Report","author":"Bruni L","year":"2019"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01910-17"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqy084"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-1353"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30375"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6833a2"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj297"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.10400"}],"container-title":["Cancer Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncy.22267","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.22267","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncy.22267","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.22267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:29:30Z","timestamp":1760272170000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncy.22267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,3]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/cncy.22267"],"URL":"https:\/\/doi.org\/10.1002\/cncy.22267","archive":["Portico"],"relation":{},"ISSN":["1934-662X","1934-6638"],"issn-type":[{"value":"1934-662X","type":"print"},{"value":"1934-6638","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,3]]},"assertion":[{"value":"2019-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}