{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:16:38Z","timestamp":1790885798919,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009051","name":"Secretar\u00eda de Salud","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010454","name":"Bracco Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010454","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008371","name":"UCLA Chicano Studies Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008371","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["SALUD\u20102013\u20101\u2010202468"],"award-info":[{"award-number":["SALUD\u20102013\u20101\u2010202468"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The goal of this study was to determine whether the detection of histologically confirmed cases of cervical high\u2010grade squamous intraepithelial lesions or worse (HSIL+) can be increased by having each liquid\u2010based cytology (LBC) slide read by 2 cytotechnologists as part of routine screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Over 36,212 women aged 30 to 64\u00a0years participated in the Forwarding Research for Improved Detection and Access for Cervical Cancer Screening and Triage (FRIDA) Study in Mexico between 2013 and 2016. For each participant, 2 cervical samples were collected at the same clinic visit, one to test for high\u2010risk human papillomavirus (hrHPV) and the other for LBC, which was used to triage those with a hrHPV positive result. LBC slides were evaluated by 7 cytotechnologists, with each slide read independently by 2 blinded cytotechnologists. All women with atypical cells of undetermined significance or a worse result were referred to colposcopy for further evaluation and diagnosis. Three pathologists evaluated the biopsy specimens to confirm the final HSIL+ diagnosis. The HSIL+ detection rates for the single versus double reading were estimated and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3,914 women with a positive hrHPV result were triaged with LBC. The first and second cytology readings resulted in 43 HSIL+ cases detected; the double\u2010reading strategy detected 9 additional HSIL+ cases, resulting in a total of 52 HSIL+ cases. The HSIL+ detection rate increased from 10.99\/1000 with a single reading to 13.29\/1000 with the double\u2010reading strategy (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A 20.9% increase in HSIL+ cases detected was achieved with a double reading of the LBC slides in this sample of hrHPV\u2010positive women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22303","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T09:39:37Z","timestamp":1591781977000},"page":"715-724","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Benefit of double\u2010reading cytology smears as a triage strategy among high\u2010risk human papillomavirus\u2013positive women in Mexico"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2586-4396","authenticated-orcid":false,"given":"Paula","family":"Ram\u00edrez\u2010Palacios","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n Epidemiol\u00f3gica y en Servicios de Salud, Delegaci\u00f3n Morelos Instituto Mexicano del Seguro Social Cuernavaca Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Fielding School of Public Health University of California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0601-357X","authenticated-orcid":false,"given":"Yvonne N.","family":"Flores","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Epidemiol\u00f3gica y en Servicios de Salud, Delegaci\u00f3n Morelos Instituto Mexicano del Seguro Social Cuernavaca Mexico"},{"name":"Department of Health Policy and Management and Kaiser Permanente Center for Health Equity Fielding School of Public Health University of California Los Angeles California"},{"name":"UCLA Cancer Prevention and Control Research Center, Fielding School of Public Health and Jonsson Comprehensive Cancer Center University of California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6150-2181","authenticated-orcid":false,"given":"Catherine M.","family":"Crespi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Fielding School of Public Health University of California Los Angeles California"},{"name":"UCLA Cancer Prevention and Control Research Center, Fielding School of Public Health and Jonsson Comprehensive Cancer Center University of California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Lazcano\u2010Ponce","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Salud Poblacional. Instituto Nacional de Salud P\u00fablica Cuernavaca Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Alvarez\u2010Escobedo","sequence":"additional","affiliation":[{"name":"Unidad de Medicina Familiar, Hospital General Regional No. 1 Instituto Mexicano del Seguro Social Cuernavaca Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Torres\u2010Ibarra","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Salud Poblacional. Instituto Nacional de Salud P\u00fablica Cuernavaca Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice","family":"Rivera\u2010Paredez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Salud Poblacional. Instituto Nacional de Salud P\u00fablica Cuernavaca Mexico"},{"name":"Centro de Investigaci\u00f3n en Pol\u00edticas, Poblaci\u00f3n y Salud, Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-206X","authenticated-orcid":false,"given":"Leith","family":"Le\u00f3n\u2010Maldonado","sequence":"additional","affiliation":[{"name":"C\u00e1tedra CONACYT\u2010Instituto Nacional de Salud P\u00fablica Cuernavaca Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00ed","family":"Hern\u00e1ndez\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Salud Poblacional. Instituto Nacional de Salud P\u00fablica Cuernavaca Mexico"},{"name":"Centro de Investigaci\u00f3n en Pol\u00edticas, Poblaci\u00f3n y Salud, Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5313-2432","authenticated-orcid":false,"given":"Indira R.","family":"Mendiola\u2010Pastrana","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Salud Poblacional. Instituto Nacional de Salud P\u00fablica Cuernavaca Mexico"},{"name":"Centro de Investigaci\u00f3n en Pol\u00edticas, Poblaci\u00f3n y Salud, Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5598-5439","authenticated-orcid":false,"given":"Pablo","family":"M\u00e9ndez\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Calidad y Educaci\u00f3n en Salud Secretaria de Salud Tlaxcala Santa Ana Chiautempan Mexico"},{"name":"Facultad de Ciencias de la Salud Universidad Aut\u00f3noma de Tlaxcala Zacatelco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Cuzick","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Preventive Medicine Centre for Cancer Prevention Queen Mary University of London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Carmona","sequence":"additional","affiliation":[{"name":"Laboratorio CITOMED Cuernavaca M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Laboratorio de Citolog\u00eda Laboratorio Estatal de Salud P\u00fablica Tlaxcala M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Montiel\u2010Cordero","sequence":"additional","affiliation":[{"name":"Hospital de la Mujer de Tlaxcala Tlaxcala M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4217-1521","authenticated-orcid":false,"given":"Joacim","family":"Meneses\u2010Le\u00f3n","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Salud Poblacional. Instituto Nacional de Salud P\u00fablica Cuernavaca Mexico"},{"name":"Centro de Investigaci\u00f3n en Pol\u00edticas, Poblaci\u00f3n y Salud, Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5113-299X","authenticated-orcid":false,"given":"Jorge","family":"Salmer\u00f3n","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Salud Poblacional. Instituto Nacional de Salud P\u00fablica Cuernavaca Mexico"},{"name":"Centro de Investigaci\u00f3n en Pol\u00edticas, Poblaci\u00f3n y Salud, Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the FRIDA Study Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v6.i6.281"},{"key":"e_1_2_8_3_1","unstructured":"World Health Organization.Cervical cancer. Accessed May 28 2020.https:\/\/www.who.int\/cancer\/prevention\/diagnosis\u2010screening\/cervical\u2010cancer\/en\/"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_8_5_1","unstructured":"BruniL AlberoG SerranoB et al.ICO\/IARC Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in the World. Summary Report 17 June2019. Accessed on May 28 2020.https:\/\/www.hpvcentre.net\/statistics\/reports\/XWX.pdf"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92695-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910540408"},{"issue":"3","key":"e_1_2_8_8_1","first-page":"S3\/63","article-title":"Chapter 7: Achievements and limitations of cervical cytology screening","volume":"24","author":"Kitchener HC","year":"2006","journal-title":"Vaccine"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-2659"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-0128(99)00006-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000501)86:3<440::AID-IJC22>3.0.CO;2-A"},{"issue":"2","key":"e_1_2_8_12_1","first-page":"s208","article-title":"Regional differences in breast and cervical cancer mortality in Mexico between 1979\u20102006 [in Spanish]","volume":"51","author":"Palacio\u2010Mejia LS","year":"2009","journal-title":"Salud Publica Mex"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-10-200005160-00009"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9694-3"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9598-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2015.05.013"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333567"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328615"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21424"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10921"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368041"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP6LW4SYBTISOW"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.15781"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50223"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.09.006"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70360-2"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21955"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn444"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.21149\/spm.v58i2.7789"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1782-x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318254f90c"},{"key":"e_1_2_8_33_1","unstructured":"Secretar\u00eda de Salud"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/001316446002000104"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1009213286"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.2307\/2530820"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-1038"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.11.1500"},{"key":"e_1_2_8_39_1","first-page":"92","article-title":"Interobserver reproducibility with LiquiPrep liquid\u2010based cervical cytology screening in a developing country","volume":"9","author":"Settakorn J","year":"2008","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12907-017-0058-8"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21783"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0115-CP"}],"container-title":["Cancer Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncy.22303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.22303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncy.22303","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.22303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:38:42Z","timestamp":1760272722000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncy.22303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,10]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/cncy.22303"],"URL":"https:\/\/doi.org\/10.1002\/cncy.22303","archive":["Portico"],"relation":{},"ISSN":["1934-662X","1934-6638"],"issn-type":[{"value":"1934-662X","type":"print"},{"value":"1934-6638","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,10]]},"assertion":[{"value":"2019-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}