{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:24:12Z","timestamp":1778743452827,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has established distinct diagnostic categories for reporting cytopathological findings, and each is associated with a defined risk of malignancy (ROM). However, the ROM is applied at the overall category level and is not specific for particular morphological entities within a category. Here, the diagnostic performance of the MSRSGC for pleomorphic adenoma (PA) and Warthin tumor (WT) is reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The pathology archives of 11 institutions from 4 countries were retrospectively searched to identify all salivary gland fine\u2010needle aspiration (FNA) biopsies with a differential or definitive diagnosis of PA or WT and all resection specimens with a diagnosis of PA or WT; only paired cases were included. All FNA diagnoses were retrospectively classified according to the MSRSGC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1250 cases met the inclusion criteria, and they included 898 PA cases and 352 WT cases. The ROM in the benign neoplasm category was 3.0% and 1.3% for cases with a differential or definitive diagnosis of PA and WT, respectively. The ROM in the salivary gland neoplasm with uncertain malignant potential (SUMP) category was 2.7% and 18.8% for PA and WT, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0277). The diagnostic accuracy for PA and WT was 95.1% and 96.1%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The diagnostic accuracy for PA and WT on FNA is high. Furthermore, these findings highlight the difference in the ROMs associated with 2 specific differential diagnoses in the SUMP category: basaloid neoplasms and oncocytoid neoplasms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22339","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T21:58:51Z","timestamp":1596837531000},"page":"43-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Assessing the diagnostic accuracy for pleomorphic adenoma and Warthin tumor by employing the Milan System for Reporting Salivary Gland Cytopathology: An international, multi\u2010institutional study"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5119-2474","authenticated-orcid":false,"given":"Derek B.","family":"Allison","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Kentucky College of Medicine Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander P.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Kentucky College of Medicine Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"An","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Adam","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khurram","family":"Shafique","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0145-0217","authenticated-orcid":false,"given":"Kartik","family":"Viswanathan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine NewYork\u2010Presbyterian, Weill Cornell Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Eykman","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Vincent Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rema A.","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology Montefiore Medical Center Bronx New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-4333","authenticated-orcid":false,"given":"Austin","family":"Wiles","sequence":"additional","affiliation":[{"name":"Department of Pathology Virginia Commonwealth University Richmond Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1825-4637","authenticated-orcid":false,"given":"G\u00fcliz A.","family":"Barkan","sequence":"additional","affiliation":[{"name":"Department of Pathology Loyola University Medical Center Maywood Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritu","family":"Nayar","sequence":"additional","affiliation":[{"name":"Department of Pathology Northwestern University Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Fadda","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology and Histology Agostino Gemelli School of Medicine, Catholic University of the Sacred Heart Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celeste N.","family":"Powers","sequence":"additional","affiliation":[{"name":"Department of Pathology Virginia Commonwealth University Richmond Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3819-4229","authenticated-orcid":false,"given":"Esther Diana","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology and Histology Agostino Gemelli School of Medicine, Catholic University of the Sacred Heart Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1812-8729","authenticated-orcid":false,"given":"Momin T.","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine NewYork\u2010Presbyterian, Weill Cornell Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Z.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4089-0450","authenticated-orcid":false,"given":"Ivana","family":"Kholov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pathology Fimlab Laboratories Tampere Finland"},{"name":"Faculty of Medicine and Health Technology Tampere University Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lester J.","family":"Layfield","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Missouri School of Medicine Columbia Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Field","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Vincent Hospital 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