{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:24:50Z","timestamp":1791408290578,"version":"4.3.3"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015809","name":"Ministry of Natural Resources of the People's Republic of China","doi-asserted-by":"publisher","award":["ZSDHJJ201801"],"award-info":[{"award-number":["ZSDHJJ201801"]}],"id":[{"id":"10.13039\/100015809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972804"],"award-info":[{"award-number":["81972804"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The atypia of an undetermined significance\/follicular lesion of undetermined significance (AUS\/FLUS) category in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is a heterogeneous category, which includes various cell patterns. The subclassification of AUS\/FLUS was suggested in the 2017 TBSRTC. However, the risk of malignancy (ROM) associated with different subgroups remains unresolved. Herein, AUS\/FLUS aspirates were subclassified, from which the ROM of each subgroup was determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All cases undergoing fine\u2010needle aspiration (FNA) from July 2013 to December 2018 were reviewed. Of 12,913 thyroid FNAs, 1053 (8.2%) were AUS\/FLUS. The slides of 222 patients with AUS\/FLUS with surgical follow\u2010up were reviewed and subclassified according to the recommendations of the 2017 TBSRTC. There were 195 aspirates consistently diagnosed as AUS\/FLUS and subclassified as cytologic atypia 1 (AUS\u2010C1); cytologic atypia 2 (AUS\u2010C2); architectural atypia (AUS\u2010A); cytologic and architectural atypia (AUS\u2010C&amp;A); H\u00fcrthle cell aspirates (AUS\u2010H); atypia, not otherwise specified (AUS\u2010NOS); and atypical lymphoid cells, rule out lymphoma (AUS\u2010L).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Malignancy was identified in 83.3% (185 of 222) of the AUS\/FLUS nodules. The AUS\u2010C1 group was the most common (62.1%), followed by the AUS\u2010C&amp;A (12.8%), AUS\u2010C2 (10.8%), AUS\u2010H (6.7%), AUS\u2010NOS (5.6%), AUS\u2010L (1.5%), and AUS\u2010A (0.5%) groups. AUS\u2010C1 had the highest ROM (92.6%) among the groups and varied significantly from that of the AUS\u2010C&amp;A (\n                      <jats:italic>P<\/jats:italic>\n                      = .171), AUS\u2010C2 (\n                      <jats:italic>P<\/jats:italic>\n                      = .001), AUS\u2010H (\n                      <jats:italic>P<\/jats:italic>\n                      = .001), and AUS\u2010NOS (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001) groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>As a heterogeneous category of TBSRTC, the ROM for AUS\/FLUS varies greatly among medical centers. Subclassification of AUS\/FLUS might be helpful in identifying nodules with a high ROM in this category and improving the management of such nodules.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncy.22417","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T16:19:50Z","timestamp":1623946790000},"page":"642-648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Subclassification of the Bethesda Category III (AUS\/FLUS): A study of thyroid FNA cytology based on ThinPrep slides from the National Cancer Center in China"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0711-3860","authenticated-orcid":false,"given":"Huan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Pathology National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HuiQin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LinLin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhiHui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-87666-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-60570-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23472"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2019.08.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12352"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21823"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20195"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2013.09.022"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496600"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.636"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0155"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20124"},{"key":"e_1_2_8_15_1","first-page":"195","article-title":"The indeterminate thyroid fine\u2010needle aspiration: experience from an academic center using terminology similar to that proposed in the 2007 National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference","volume":"117","author":"Nayar 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