{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:47:52Z","timestamp":1781070472009,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Urine cytology is an important screening tool in the diagnosis of high\u2010grade urothelial carcinoma. Diagnosis in urine samples follows criteria outlined by The Paris System for Reporting Urinary Cytology (TPS). However, cytologic characteristics of the recently described urothelial carcinoma in situ with plasmacytoid features (P\u2010CIS) have not been described, and it is unknown whether they conform to TPS criteria for high\u2010grade urothelial carcinoma. This study was aimed at better characterizing possibly unique cytologic features of P\u2010CIS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors collected urine cytology specimens from patients with subsequent bladder biopsy\u2013proven P\u2010CIS. Specimens were re\u2010reviewed according to the TPS criteria. The proposed cytologic features of P\u2010CIS (eccentric, enlarged, and hyperchromatic nuclei) were evaluated; this included the reproducibility of 3 cytopathologists for the proposed cytologic features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010four urine specimens from 18 patients with P\u2010CIS\u2013diagnosed bladder biopsies were identified. The TPS diagnoses of the 74 urine cytology specimens were as follows: negative for high\u2010grade urothelial carcinoma (n = 26), atypical urothelial cells (n = 26), suspicious for high\u2010grade urothelial carcinoma (n = 12), and high\u2010grade urothelial carcinoma (n = 10). Only 7 urine specimens met the proposed cytologic criteria for P\u2010CIS, and they had TPS diagnoses of negative for high\u2010grade urothelial carcinoma (n = 1), atypical urothelial cells (n = 3), and high\u2010grade urothelial carcinoma (n = 3). The \u03ba interobserver agreement ranged from poor to fair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The features of P\u2010CIS on urine cytology are subtle and infrequently reproducible and often do not meet the TPS criteria for diagnosis as high\u2010grade urothelial carcinoma. In specimens that do not meet TPS criteria for high\u2010grade urothelial carcinoma, P\u2010CIS cytology in isolation would be best classified as atypical urothelial cells.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22445","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T11:55:10Z","timestamp":1619438110000},"page":"798-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Urine cytology findings in patients with biopsy\u2010confirmed urothelial carcinoma in situ with plasmacytoid features"],"prefix":"10.1002","volume":"129","author":[{"given":"Meredith M.","family":"Nichols","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan P.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse K.","family":"McKenney","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlo M.","family":"Nicolas","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"McIntire","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0375-1964","authenticated-orcid":false,"given":"Maria Luisa C.","family":"Policarpio\u2010Nicolas","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Cleveland Clinic Cleveland 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