{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:35:37Z","timestamp":1780083337295,"version":"3.54.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Intraductal carcinoma of the salivary gland (IDC) is a rare cancer with potential actionable targets, including <jats:italic>RET<\/jats:italic> fusions. Histologic and molecular features of IDC were recently reported, but cytomorphologic data are limited. In the largest multi\u2010institutional fine\u2010needle aspiration (FNA) series, the authors describe the cytomorphologic features of 13 IDC cases with available clinical, radiologic, histopathologic, and molecular data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cases included 13 FNAs for 9 low\u2010grade (LG) IDCs and 4 high\u2010grade (HG) IDCs with corresponding histopathology and available molecular, imaging, and clinical data. Smears and liquid\u2010based preparations available for 12 FNAs were semiquantitatively scored for key cytomorphologic findings and correlated with the corresponding resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LG IDC FNAs showed a cellular, biphasic population of large, atypical ductal cells with mildly pleomorphic nuclei in a clean background and a minor population of small, uniform myoepithelial cells. In contrast, all HG IDC FNAs showed predominantly ductal cells with marked nuclear pleomorphism, coarse chromatin, and necrosis. With the Milan system, most LG and HG IDC FNAs were classified as either salivary gland neoplasms of uncertain malignant potential (54%) or malignant (31%). Immunohistochemistry showed ductal epithelial reactivity with mammaglobin, androgen receptor, and S100, whereas myoepithelial cells were positive for p63 and\/or calponin. Among cases with next\u2010generation sequencing, 4 LG IDCs showed <jats:italic>NCOA4\u2010RET<\/jats:italic> gene fusions, whereas an HG IDC showed <jats:italic>HRAS<\/jats:italic> and <jats:italic>PIK3CA<\/jats:italic> mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The cytomorphology of IDC overlaps with other benign and malignant salivary gland neoplasms. Immunohistochemistry limits the differential diagnosis, but definitive classification requires molecular analysis. A diagnosis of IDC has potential implications for patient management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22504","type":"journal-article","created":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T09:14:34Z","timestamp":1633166074000},"page":"928-946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cytomorphologic features of intraductal salivary gland carcinoma: A multi\u2010institutional study of 13 FNA cases with histologic, molecular, and clinical correlations"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-0001","authenticated-orcid":false,"given":"Kartik","family":"Viswanathan","sequence":"first","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital and Harvard Medical School Boston 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