{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:40:01Z","timestamp":1776314401294,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Pediatric salivary gland fine\u2010needle aspiration (FNA) is uncommon with a higher frequency of inflammatory lesions and a small proportion of malignancies. This international, multi\u2010institutional cohort evaluated the application of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) and the risk of malignancy (ROM) for each diagnostic category.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Pediatric (0\u2010 to 21\u2010year\u2010old) salivary gland FNA specimens from 22 international institutions of 7 countries, including the United States, England, Italy, Greece, Finland, Brazil, and France, were retrospectively assigned to an MSRSGC diagnostic category as follows: nondiagnostic, nonneoplastic, atypia of undetermined significance (AUS), benign neoplasm, salivary gland neoplasm of uncertain malignant potential (SUMP), suspicious for malignancy (SM), or malignant. Cytology\u2010histology correlation was performed where available, and the ROM was calculated for each MSRSGC diagnostic category.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The cohort of 477 aspirates was reclassified according to the MSRSGC as follows: nondiagnostic, 10.3%; nonneoplastic, 34.6%; AUS, 5.2%; benign neoplasm, 27.5%; SUMP, 7.5%; SM, 2.5%; and malignant, 12.4%. Histopathologic follow\u2010up was available for 237 cases (49.7%). The ROMs were as follows: nondiagnostic, 5.9%; nonneoplastic, 9.1%; AUS, 35.7%; benign neoplasm, 3.3%; SUMP, 31.8%; SM, 100%; and malignant, 100%. Mucoepidermoid carcinoma was the most common malignancy (18 of 237; 7.6%), and it was followed by acinic cell carcinoma (16 of 237; 6.8%). Pleomorphic adenoma was the most common benign neoplasm (95 of 237; 40.1%).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The MSRSGC can be reliably applied to pediatric salivary gland FNA. The ROM of each MSRSGC category in pediatric salivary gland FNA is relatively similar to the ROM of each category in adult salivary gland FNA, although the reported rates for the different MSRSGC categories are variable across institutions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22556","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T14:23:51Z","timestamp":1643207031000},"page":"370-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Application of the Milan System for Reporting Salivary Gland Cytopathology in pediatric patients: An international, multi\u2010institutional study"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3273-4802","authenticated-orcid":false,"given":"Zahra","family":"Maleki","sequence":"first","affiliation":[{"name":"Department of Pathology Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Saoud","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-0001","authenticated-orcid":false,"given":"Kartik","family":"Viswanathan","sequence":"additional","affiliation":[{"name":"Department of Pathology Emory University Hospital Midtown Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irem","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Pathology Loyola University Medical Center Maywood Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkka","family":"Tommola","sequence":"additional","affiliation":[{"name":"Fimlab Laboratories Tampere Finland"},{"name":"Faculty of Medicine and Health Technology Tampere University Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel T.","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Kentucky College of Medicine Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amer","family":"Heider","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Petrone","sequence":"additional","affiliation":[{"name":"Department of Pathology Catholic University of Sacred Heart University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4808-2714","authenticated-orcid":false,"given":"Vickie Y.","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"Centeno","sequence":"additional","affiliation":[{"name":"Department of Pathology Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9438-226X","authenticated-orcid":false,"given":"Mauro","family":"Saieg","sequence":"additional","affiliation":[{"name":"Department of Pathology A. 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