{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:20:56Z","timestamp":1788456056771,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Atypical squamous cells of undetermined significance (ASC\u2010US) is the most frequent but ambiguous abnormal Papanicolaou (Pap) interpretation and is generally triaged by high\u2010risk human papillomavirus (hrHPV) testing before colposcopy. This study aimed to evaluate the performance of an artificial intelligence (AI)\u2010based triage system to predict ASC\u2010US cytology for cervical intraepithelial neoplasia 2+ lesions (CIN2+).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>More than 60,000 images were used to train this proposed deep learning\u2010based ASC\u2010US triage system, where both cell\u2010level and slide\u2010level information were extracted. In total, 1967 consecutive ASC\u2010US Paps from 2017 to 2019 were included in this study. Histological follow\u2010ups were retrieved to compare the triage performance between the AI system and hrHPV in 622 patients with simultaneous hrHPV testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In the triage of women with ASC\u2010US cytology for CIN2+, our system attained equivalent sensitivity (92.9%; 95% confidence interval [CI], 75.0%\u201098.8%) and higher specificity (49.7%; 95% CI, 45.6%\u201053.8%) than hrHPV testing (sensitivity: 89.3%; 95% CI, 70.6%\u201097.2%; specificity: 34.3%; 95% CI, 30.6%\u201038.3%) without requiring additional patient examination or testing. Additionally, the independence of this system from hrHPV testing (\u03ba = 0.138) indicated that these 2 different methods could be used to triage ASC\u2010US as an alternative way.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This de novo deep learning\u2010based system can triage ASC\u2010US cytology for CIN2+ with a performance superior to hrHPV testing and without incurring additional expenses.;<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22560","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T14:46:26Z","timestamp":1647355586000},"page":"407-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Scrutinizing high\u2010risk patients from ASC\u2010US cytology via a deep learning model"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1052-118X","authenticated-orcid":false,"given":"Xiang","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Pathology, Obstetrics and Gynecology Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chu","sequence":"additional","affiliation":[{"name":"Ping An Healthcare Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxue","family":"Guo","sequence":"additional","affiliation":[{"name":"Ping An Healthcare Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuzhi","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Obstetrics and Gynecology Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Pathology, Obstetrics and Gynecology Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Lou","sequence":"additional","affiliation":[{"name":"Ping An Healthcare Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanfeng","family":"Lv","sequence":"additional","affiliation":[{"name":"Ping An Healthcare Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guotong","family":"Xie","sequence":"additional","affiliation":[{"name":"Ping An Healthcare Technology  Shanghai China"},{"name":"Ping An Healthcare and Technology Company Limited  Shanghai China"},{"name":"Ping An International Smart City Technology Company  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5359-8841","authenticated-orcid":false,"given":"Keqin","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1501"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/842037"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21139"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2020.2983186"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21451"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1460-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910510403"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27850"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013206"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22180"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2020.07.133"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPXANG59GPHJNU"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018-0603-CP"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328554"},{"key":"e_1_2_8_17_1","first-page":"728","article-title":"Spontaneous regression of low\u2010grade cervical intraepithelial lesions is positively improved by topical bovine colostrum preparations (GINEDIE(R)). 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