{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:34:19Z","timestamp":1761989659131,"version":"build-2065373602"},"reference-count":68,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Mesenchymal neoplasms of the parotid gland (PG) and para\u2010pharyngeal (PP) space are distinctly uncommon. Fine\u2010needle aspiration (FNA) biopsy experience with nonlipomatous neoplasms from this site is reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Cytopathology and surgical pathology files were examined for mesenchymal PG and PP space neoplasms. FNA biopsy was performed using standard technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Twenty\u2010two PG and\/or PP aspirates from 20 adults (male:female = 1.1:1; age range, 19\u201084 years, mean age, 50 years) and a 10\u2010week\u2010old infant met inclusion criteria. Biopsy sites included PG (17, 77%) or PP space (5, 23%). Five of 6 malignant neoplasms (83%) were called malignant cytologically. Only 7 of 11 (63%) benign neoplasms were recognized as a benign neoplasm. None of 5 solitary fibrous tumor (SFT) cases were correctly recognized. Conversion to the Milan classification showed 8 (36%) FNA cases diagnosed as benign neoplasm, 6 (27%) malignant neoplasm, 4 (18%) neoplasm of uncertain malignant potential, 2 (9%) nondiagnostic, and single cases of suspicious for malignancy and nonneoplastic. There was 1 false\u2010positive and no false\u2010negative FNA diagnoses. Ancillary testing in 10 (45%) aspirates helped substantiate a correct specific diagnosis in 3 malignant and 3 benign cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>FNA biopsy of nonlipomatous mesenchymal SG neoplasms is particularly challenging. Less than half (9 of 11, 41%) had specific FNA diagnoses that correctly matched the tissue diagnoses or clinical outcome. Accurate Milan categorization was superior for malignant neoplasms (5 of 6, 83%) in contrast to benign neoplasms (7 of 11, 63%), or neoplasms of uncertain malignant potential (SFT) (2 of 5, 40%).;<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22562","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T12:08:28Z","timestamp":1645618108000},"page":"443-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mesenchymal neoplasms of the parotid gland and parapharyngeal space: an FNA cytologic study of 22\u00a0nonlipomatous tumors"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0531-2690","authenticated-orcid":false,"suffix":"Jr","given":"Paul E.","family":"Wakely","sequence":"first","affiliation":[{"name":"Department of Pathology The Ohio State University Wexner Medical Center James Cancer Hospital and Solove Research Institute  Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.55418\/9781933477947"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0488-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1008020"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2007.12.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199103000-00005"},{"key":"e_1_2_7_7_1","first-page":"312","article-title":"A study of fine\u2010needle aspiration cytology of salivary gland lesions with histopathological corroboration","volume":"103","author":"Bandyopadhyay A","year":"2005","journal-title":"J Indian Med Assoc"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840070311"},{"key":"e_1_2_7_9_1","first-page":"353","article-title":"Cytodiagnosis of 112 salivary gland lesions. 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