{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:15:25Z","timestamp":1772997325974,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>With the development of new technologies and the changing patient profiles, cytopathology departments receive increasing numbers of adrenal gland cytology specimens. In this study, the authors analyzed archival adrenal gland cytology cases and attempted to implement a diagnostic reporting system.<\/jats:p><\/jats:sec><jats:sec><jats:title>DESIGN<\/jats:title><jats:p>Retrospective electronic medical record search was performed for adrenal gland cytology specimens in seven tertiary care centers. The cytology diagnoses were grouped in 7 categories: nondiagnostic, nonneoplastic, benign adrenal cortical elements (BACE), primary neoplasm of noncortical origin (NONC), atypia of undetermined significance (AUS), suspicious for malignancy (SM), and malignant (MAL). If available, histopathology results of concurrent and\/or follow\u2010up biopsies and\/or resections were documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 473 adrenal gland cytology cases were included. BACE cases comprised 21.8%, whereas MAL cases were 57.5% of all cases. For BACE and MAL categories, there were 100% and 98.9% correlation, respectively, in the cases with histopathology follow\u2010up. Six of 10 NONC cases had histopathology diagnoses and there were 3 pheochromocytomas and 3 schwannomas. Twenty\u2010one AUS cases had histology follow\u2010up and 10 (47.6%) of them were malignant. Six cases of SM had histopathology follow\u2010up, and all of them were malignant on the follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The authors propose a 7\u2010tier diagnostic scheme for adrenal gland cytology. The risk of malignancy was 98.9% in MAL cases (87\/88) in the cohort. The only case with discordance was reported as \u201cadrenal cortical adenoma with marked atypia\u201d' on resection. There was no difference between endoscopic ultrasound\u2010guided and percutaneous methods. Further studies are needed to validate and make this approach universal.;<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22564","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T11:55:26Z","timestamp":1646394926000},"page":"423-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Adrenal gland cytology reporting: a multi\u2010institutional proposal for a standardized reporting system"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8986-8567","authenticated-orcid":false,"given":"Levent","family":"Trabzonlu","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Loyola University Medical Center  Maywood Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3000-3686","authenticated-orcid":false,"given":"Lucy","family":"Jager","sequence":"additional","affiliation":[{"name":"Department of Pathology Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8967-2687","authenticated-orcid":false,"given":"Seena","family":"Tabibi","sequence":"additional","affiliation":[{"name":"Department of Pathology The Johns Hopkins Hospital  Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret L.","family":"Compton","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology Vanderbilt University Medical Center  Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0874-3207","authenticated-orcid":false,"given":"Vivian L.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology Vanderbilt University Medical Center  Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonca","family":"Kanber","sequence":"additional","affiliation":[{"name":"Department of Pathology McGill University Health Centre  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4542-7238","authenticated-orcid":false,"given":"Valentina","family":"Robila","sequence":"additional","affiliation":[{"name":"Department of Pathology Virginia Commonwealth University Health System  Richmond 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