{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T22:21:49Z","timestamp":1785277309238,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Secretory carcinoma (SC) of the salivary gland is a rare entity with limited published literature on cytomorphology. The authors present the largest cohort to date of SC fine\u2010needle aspiration (FNA) cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>FNA cases of histologically confirmed SC were retrospectively retrieved from 12 academic institutions in the United States, Italy, Finland, and Brazil. The collated data included patient demographics, imaging findings, cytopathologic diagnoses according to the Milan System for Reporting Salivary Gland Cytopathology, cytomorphologic characteristics, and immunohistochemical\/molecular profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In total, 40 SCs were identified (male\u2010to\u2010female ratio, 14:26) in patients with a mean age of 52 years (age range, 13\u201080 years). Ultrasound imagining revealed a hypoechoic, ovoid, poorly defined, or lobulated mass. The most common primary site was the parotid gland (30 of 40 tumors). Regional lymph node metastasis (9 patients) and distant metastasis (4 patients; brain, liver, lungs, and mediastinum) were noted. Two patients died of disease. FNA smears were cellular and demonstrated mainly large, round cells with intracytoplasmic vacuoles or granules and round\u2010to\u2010oval nuclei with smooth nuclear contour, minimal irregularities, and prominent nucleoli arranged predominantly in clusters, papillary formations, and single cells. The background was variable and contained inflammatory cells, mucin, or proteinaceous material. The diagnoses were malignant (19 of 38 tumors; 50%), suspicious for malignancy (10 of 38 tumors; 26%), salivary gland neoplasm of uncertain malignant potential (7 of 38 tumors; 18%), and atypia of undetermined significance (2 of 38 tumors; 6%) according to the Milan System for Reporting Salivary Gland Cytopathology. Two malignant cases (2 of 40 tumors; 5%) were metastases. The neoplastic cells were immunoreactive for S100 (23 of 24 tumors), mammaglobin (18 of 18 tumors), GATA\u20103 (13 of 13 tumors), AE1\/AE3 (7 of 7 tumors), and vimentin (6 of 6 tumors). <jats:italic>ETV6\u2010NTRK3<\/jats:italic> fusion was detected in 32 of 33 tumors by fluorescence in situ hybridization (n = 32) and next\u2010generation sequencing (n = 1).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Familiarity with cytomorphologic features and the immunohistochemical\/molecular profile of SC can enhance diagnostic accuracy.;<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22574","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T14:04:07Z","timestamp":1649253847000},"page":"684-694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Secretory carcinoma of the salivary gland, a rare entity: An international multi\u2010institutional study"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-4333","authenticated-orcid":false,"given":"Austin B.","family":"Wiles","sequence":"first","affiliation":[{"name":"Department of Pathology Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Gabrielson","sequence":"additional","affiliation":[{"name":"Department of Pathology The Johns Hopkins Hospital  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubair W.","family":"Baloch","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital of the University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9043-7171","authenticated-orcid":false,"given":"William C.","family":"Faquin","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts 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