{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:45:18Z","timestamp":1771231518431,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The salivary gland neoplasm of uncertain malignant potential (SUMP) category in the Milan System is diagnostically challenging. This study aims to validate a modified scheme for subcategorizing SUMP in a large multi\u2010institutional cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Retrospective review of salivary gland fine\u2010needle aspirations (FNAs) from 10 institutions were classified based on the Milan System. Cases diagnosed as SUMP with available cytology slides and surgical follow\u2010up were retrieved for review and subcategorized based on a modified scheme as follows: basaloid SUMP (B1: absent\/scant nonfibrillary matrix; B2: presence of nonfibrillary\/mixed\u2010type matrix), oncocytic\/oncocytoid SUMP (O1: with mucinous background; O2: without mucinous background), and SUMP not otherwise specified (NOS).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 742 (7.5%) cases from 9938 consecutive salivary gland FNAs were classified as SUMP. Among them, 525 (70.8%) had surgical follow\u2010up and 329 (62.7%) were available for review. The overall risk of malignancy (ROM) of SUMP was 40.4%. There were 156 cases (47.4%) subcategorized as basaloid SUMP with a ROM of 36.5%, 101 (30.7%) as oncocytic\/oncocytoid SUMP with a ROM of 52.5%, and 72 (21.9%) as SUMP NOS with a ROM of 31.9%. The ROM of oncocytic\/oncocytoid SUMP was significantly higher than basaloid SUMP (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0142) and SUMP NOS (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0084). No significant differences in ROM were noted between B1 and B2 (36.7% vs 36.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.0000) and O1 and O2 (65.2% vs 48.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.2349).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The ROM of oncocytic\/oncocytoid SUMP was 52.5% and significantly higher than that of basaloid SUMP (36.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0142) and SUMP NOS (31.9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0084), whereas no significant differences in ROM were noted for cases with different types of extracellular matrix or background material.;<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22593","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:29:03Z","timestamp":1653956943000},"page":"511-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Multi\u2010institutional validation of a modified scheme for subcategorizing salivary gland neoplasm of uncertain malignant potential (<scp>SUMP<\/scp>)"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-2784","authenticated-orcid":false,"given":"Jen\u2010Fan","family":"Hang","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine and Institute of Clinical Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8573-7268","authenticated-orcid":false,"given":"Jaslyn Jie Lin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology National University Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min En","family":"Nga","sequence":"additional","affiliation":[{"name":"Department of Pathology National University Hospital  Singapore"},{"name":"Department of Pathology, Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Okinawa Kyodo Hospital  Naha Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiya","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Pathology University of the Ryukyus Hospital  Nishihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6888-5736","authenticated-orcid":false,"given":"Howard H.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University School of Medicine  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5119-2474","authenticated-orcid":false,"given":"Derek B.","family":"Allison","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Kentucky  Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason D.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Kentucky  Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2089-6118","authenticated-orcid":false,"given":"Oscar","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9438-226X","authenticated-orcid":false,"given":"Mauro","family":"Saieg","sequence":"additional","affiliation":[{"name":"Department of Pathology A. 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