{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:36:00Z","timestamp":1790012160367,"version":"4.0.1"},"reference-count":65,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Mucoepidermoid carcinoma (MEC) is the most common salivary gland (SG) malignancy. In this study, the author undertook analysis of a large collection of MEC cytologic cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Cytopathology files were searched for MEC cases with histopathologic confirmation. Fine\u2010needle aspiration (FNA) smears used standard technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010six cases (63 patients [M:F\u00a0=\u00a01:1; age range, 23\u201387\u2009years; mean age, 58\u2009years]) met inclusion criteria. Aspirates were primary (54 [71%]), metastatic (18 [24%]), and locally recurrent (4 [5%]). FNA sites included parotid gland (49 [64%]), regional lymph nodes (11 [14%]), submandibular gland (5 [7%]), inner canthus of eye (2 [3%]), and lung (2 [3%]); and single specimens from palate, jaw, shoulder, paranasal sinus, floor of mouth, ear canal, and effusion. Cytologic diagnoses included MEC (30 cases [39%]), suspicious for MEC (16 [21%]), non\u2010MEC carcinoma (9 [12%]), suspicious for malignancy (SM) (2 [3%], malignant (M) (1 [1%]), SG and\/or suspicious SG neoplasm (7 [8%]), atypical (3 [5%]), nonneoplastic (5 [6%]), nondiagnostic (2 [3%]), and benign SG neoplasm (1 [1%]). A total of 26% of low\u2010grade (LG) cases were diagnosed as malignant in contrast to 87% malignant in high\u2010grade (HG) cases. Cytomorphology depended on tumor grade. LG MEC contained intra\u2010 and\/or extra\u2010cellular mucin and more uniform cell and\/or nuclear morphology, whereas cytologic atypia, anisonucleosis, and keratotic cells were more typical of HG tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A malignant (M) or suspicious for malignancy (SM) cytologic interpretation was made in 76% of mucoepidermoid carcinoma (MEC) cases. In contrast to high\u2010grade MEC (97% identified as M\/SM), only 59% of low\u2010grade (LG) MEC cases were interpreted as such, illustrating the continued diagnostic challenge posed by LG MEC using fine\u2010needle aspiration biopsy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22600","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T16:05:58Z","timestamp":1654013158000},"page":"783-799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Mucoepidermoid carcinoma: Analysis of 76 cytologic cases and correlation with histologic grade"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0531-2690","authenticated-orcid":false,"suffix":"Jr","given":"Paul E.","family":"Wakely","sequence":"first","affiliation":[{"name":"Department of Pathology, The Ohio State University Wexner Medical Center James Cancer Hospital and Solove Research Institute  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.55418\/9781933477947"},{"key":"e_1_2_6_3_1","first-page":"163","volume-title":"WHO Classification of Head and Neck Tumours","author":"Brandwein\u2010Gensler M","year":"2017"},{"key":"e_1_2_6_4_1","first-page":"43","article-title":"Fine needle aspiration biopsy diagnosis of mucoepidermoid carcinoma. Statistical analysis","volume":"34","author":"Cohen MB","year":"1990","journal-title":"Acta Cytol"},{"key":"e_1_2_6_5_1","first-page":"357","article-title":"Fine needle aspiration cytology of mucoepidermoid carcinoma. A diagnostic problem","volume":"35","author":"Kumar N","year":"1991","journal-title":"Acta Cytol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.155226"},{"key":"e_1_2_6_7_1","first-page":"35","article-title":"Aspiration biopsy of salivary gland tumors: VI: morphologic studies on smears and histologic sections from mucoepidermoid carcinoma","volume":"20","author":"Zajicek J","year":"1976","journal-title":"Acta Cytol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23785"},{"key":"e_1_2_6_9_1","article-title":"A cytohistologic correlation of mucoepidermoid carcinoma: emphasizing the rare oncocytic variant","volume":"135796","author":"Wade TV","year":"2011","journal-title":"Patholog Res Int"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489419842582"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2020.02.001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199708)17:2<92::AID-DC3>3.0.CO;2-Q"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-71285-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/adpa.2003.50005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000298"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/S0046-8177(03)00418-0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23707"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194511000-00005"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.5858\/2005-129-26-PISGFC"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2019.04.001"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22532"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016486409121406"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840090222"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2020.0022"},{"key":"e_1_2_6_25_1","first-page":"287","volume-title":"Fine Needle Aspiration Biopsy. Pathology \u2010 State of the Art Reviews","author":"Zarka MA","year":"1996"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20215"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-018-0904-8"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23780"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840060111"},{"key":"e_1_2_6_30_1","first-page":"ER04","article-title":"Mucoepidermoid carcinoma of salivary gland: limitations and pitfalls on FNA","volume":"11","author":"Vasudevan G","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2021.02.001"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20951"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10240"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000332705"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980825)84:4<231::AID-CNCR8>3.0.CO;2-P"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/00313028809085213"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000521134"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-018-1941-3"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13461"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980625)84:3<153::AID-CNCR6>3.0.CO;2-P"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24581"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2021.2438"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000425)90:2<111::AID-CNCR6>3.0.CO;2-N"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199612)15:5<447::AID-DC19>3.0.CO;2-N"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11207"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325085"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199709)17:3<230::AID-DC12>3.0.CO;2-G"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199703)16:3<221::AID-DC5>3.0.CO;2-I"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2020.03.008"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.2002.00415.x"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326979"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10168"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1159\/000348248"},{"key":"e_1_2_6_54_1","first-page":"237","article-title":"Sebaceous variant of mucoepidermoid carcinoma of the salivary gland. A case report with cytohistologic correlation","volume":"37","author":"Hayes MM","year":"1993","journal-title":"Acta Cytol"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000507"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000932"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001688"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-022-01420-1"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327872"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199706)16:6<526::AID-DC11>3.0.CO;2-K"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199808)19:2<120::AID-DC11>3.0.CO;2-H"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971225)81:6<373::AID-CNCR12>3.0.CO;2-W"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22568"},{"key":"e_1_2_6_64_1","first-page":"604","article-title":"Mucoepidermoid carcinoma ex pleomorphic adenoma of the parotid gland","volume":"39","author":"Pitman MB","year":"1995","journal-title":"Acta Cytol"},{"key":"e_1_2_6_65_1","first-page":"93","article-title":"Low grade mucoepidermoid carcinoma ex pleomorphic adenoma. A diagnostic problem in fine needle aspiration biopsy","volume":"38","author":"Jacobs JC","year":"1994","journal-title":"Acta Cytol"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000291"}],"container-title":["Cancer Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.22600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncy.22600","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.22600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T17:04:02Z","timestamp":1760288642000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncy.22600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,31]]},"references-count":65,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/cncy.22600"],"URL":"https:\/\/doi.org\/10.1002\/cncy.22600","archive":["Portico"],"relation":{},"ISSN":["1934-662X","1934-6638"],"issn-type":[{"value":"1934-662X","type":"print"},{"value":"1934-6638","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,31]]},"assertion":[{"value":"2022-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}