{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T01:01:27Z","timestamp":1775696487793,"version":"3.50.1"},"reference-count":63,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) reports a 25% rate of malignancy (ROM) for the Milan I: Nondiagnostic (ND) category. We clarify the ROM of ND salivary gland fine\u2010needle aspirations (SGFNAs) based on our institutional experience and review of the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall risk of malignancy (OROM) and that for those with surgical\/flow cytometric follow\u2010up (FROM) for each category and \u201call\u2010comers\u201d were calculated for Emory SGFNAs from January 2010 through March 2021. From a literature review of 50 articles using MSRSGC, distribution of diagnoses, rates of follow\u2010up, FROM, and OROM by category were calculated. FROMs and OROMs between ND FNAs and all\u2010comers were compared. Milan I rate was compared with the ratio of Milan I OROM to all\u2010comer OROM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 819 SGFNAs at Emory, 12.8% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0105\/819) were ND. Thirty\u2010two had known follow\u2010up, with 12 (37.5%) being malignant. Nonmucinous cyst contents accounted for 26.7% of ND SGFNAs (<jats:italic>n<\/jats:italic>\u00a0=\u00a028\/105); all 7 with surgical follow\u2010up were benign. Of 50 MSRSGC studies, 18.2% (<jats:italic>n<\/jats:italic>\u00a0=\u00a02384\/13,129) of SGFNAs were classified as ND, 26.6% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0635\/2384) with known follow\u2010up. Total FROM and OROM for ND FNAs (15.7% and 4.1%, respectively) were significantly lower than those for all\u2010comers (24.9% and 11.4%, respectively) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). There was no relationship between rate of ND SGFNA and ND ROM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The ND category is associated with a lower ROM than that of all\u2010comer SGFNA patients. The \u201ctrue\u201d ROM for ND SGFNAs is likely best estimated by the 4.1% OROM. SGFNAs showing nonmucinous cyst contents have a particularly low ROM. Rate of ND SGFNAs does not influence ND ROM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22601","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T16:03:58Z","timestamp":1654013038000},"page":"800-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Nondiagnostic salivary gland <scp>FNAs<\/scp> are associated with decreased risk of malignancy compared with \u201call\u2010comer\u201d patients: Analysis of the Milan System for Reporting Salivary Gland Cytopathology with a focus on Milan I: Nondiagnostic"],"prefix":"10.1002","volume":"130","author":[{"given":"Shu K.","family":"Lui","sequence":"first","affiliation":[{"name":"Department of Pathology Emory University Hospital Midtown  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troy","family":"Tenney","sequence":"additional","affiliation":[{"name":"Department of Pathology Emory University Hospital Midtown  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick C.","family":"Mullane","sequence":"additional","affiliation":[{"name":"Department of Pathology Emory University Hospital Midtown  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-0001","authenticated-orcid":false,"given":"Kartik","family":"Viswanathan","sequence":"additional","affiliation":[{"name":"Department of Pathology Emory University Hospital Midtown  Atlanta Georgia USA"},{"name":"Winship Cancer Center  Decatur Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0409-2374","authenticated-orcid":false,"given":"Daniel J.","family":"Lubin","sequence":"additional","affiliation":[{"name":"Department of Pathology Emory University Hospital Midtown  Atlanta Georgia USA"},{"name":"Winship Cancer Center  Decatur Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24350"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20142"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12562"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21710"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015\u20130222\u2010RA"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24279"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12557"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21989"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010319\u201071285\u20107_1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23716"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.16.0716.Isoniazid"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100339(199708)17:2<92::AID\u2010DC3>3.0.CO;2\u2010Q"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-71285-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24768"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010020\u201001278\u20101"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24698"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22361"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24697"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22505"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510990"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24748"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/JOC.JOC_193_20"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24621"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510720"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22363"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24682"},{"issue":"12","key":"e_1_2_7_29_1","article-title":"The 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