{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:26:42Z","timestamp":1792715202702,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Most human papillomavirus (HPV)\u2010positive women recover from infections and do not develop cervical intraepithelial neoplasia (CIN) and cervical cancer. Additional triage approaches are needed to reduce unnecessary colposcopy referrals. The aim of this study is to determine the high\u2010risk HPV prevalence in a hospital\u2010based population and to evaluate the performance of p16\/Ki\u201067 dual\u2010stain test for the triage of high\u2010risk HPV\u2010positive women to detect precursor lesions and cervical cancer compared with the ThinPrep cytologic test (TCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a hospital\u2010based population, 100,801 women were provided with a primary HPV DNA test and only women with high\u2010risk HPV infections were triaged using TCT and p16\/Ki\u201067 dual\u2010stain test. CIN2 or worse (\u2265CIN2) or CIN3 or worse (\u2265CIN3) were defined as the clinical end points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The p16\/Ki\u201067 dual\u2010stain indicated a statistically significant higher sensitivity (82.8% vs. 66.7%%), specificity (51.6% vs. 44.4%), positive predictive value (33.2% vs. 25.8%), negative predictive value (91.2% vs. 82.1%), and accuracy (58.6% vs. 49.4%) compared with TCT examination within \u2265CIN2 cases. Similar patterns were observed for the \u2265CIN3 end point.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study demonstrated that p16\/Ki\u201067 dual\u2010stain test could achieve better performance compared with TCT examination for \u2265CIN2 or\u2009\u2265\u2009CIN3 detection, representing a promising approach as a specific and efficient triage strategy for high\u2010risk HPV\u2010positive women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncy.22628","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T08:44:55Z","timestamp":1658220295000},"page":"955-963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of p16\/Ki\u201067 dual\u2010stain as triage test for high\u2010risk\n                    <scp>HPV<\/scp>\n                    \u2010positive women: A hospital\u2010based cross\u2010sectional study"],"prefix":"10.1002","volume":"130","author":[{"given":"Xiaoyan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Yaneng Bioscience, Co, Ltd  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Shenzhen Nanshan Maternity and Child Healthcare Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Dai","sequence":"additional","affiliation":[{"name":"Yaneng Bioscience, Co, Ltd  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Shenzhen Nanshan Maternity and Child Healthcare 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