{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:40:48Z","timestamp":1760301648745,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010900","name":"Yale Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Risk assessment of gastrointestinal stromal tumor (GIST) is challenging on cytology specimens. This study aims to determine whether Ki\u201067 index evaluated on fine\u2010needle aspiration (FNA) specimens can correlate with the mitotic rate of GIST in surgical specimens and provide further risk assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases with cell blocks containing adequate tumor cells and surgical resections were included. Ki\u201067 immunostain was retrospectively performed on cell block sections, and Ki\u201067 index was calculated on the \u201chot spot\u201d areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study included 50 GIST cases from stomach (<jats:italic>n<\/jats:italic>\u00a0=\u00a045; 90%), duodenum (<jats:italic>n<\/jats:italic>\u00a0=\u00a04; 8%), and distal esophagus (<jats:italic>n<\/jats:italic>\u00a0=\u00a01; 2%). The tumor size ranged from 1.5 cm to 21 cm (mean, 5.4 cm). Based on the mitotic count, 37 GISTs (74%) had low mitotic rate (LMR) and 13 GISTs (26%) had high mitotic rate (HMR). The spindle cell, epithelioid, and mixed types accounted for 60%, 14%, and 26%\u00a0of GIST, respectively. Ki\u201067 index counted on cell block sections correlated well with mitotic count evaluated in surgical specimens (r\u00a0=\u00a00.8031). Mean Ki\u201067 index was higher in HMR than LMR groups (3.5% vs. 1%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The receiver operating characteristic curve using Ki\u201067 index to predict mitotic rate was further analyzed, and area under the curve was 0.839. Using a cutoff of 2.5% yielded a sensitivity of 70% at 92% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates good correlations between Ki\u201067 index and mitotic count or risk stratification, suggesting that Ki\u201067 index evaluated on cytology specimens may offer a promising approach to preoperatively predict the mitotic rate and risk of GIST.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22630","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T09:15:45Z","timestamp":1658740545000},"page":"974-982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ki\u201067 index assessment on <scp>FNA<\/scp> specimens of gastrointestinal stromal tumor: Correlation with mitotic rate and potential predictive value for risk stratification"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8916-5132","authenticated-orcid":false,"given":"Xi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-1146","authenticated-orcid":false,"given":"Rita","family":"Abi\u2010Raad","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiming","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8725-5940","authenticated-orcid":false,"given":"Guoping","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Yale Cancer Center Yale University School of Medicine  New\u00a0Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","first-page":"e4120","article-title":"Incidence of gastrointestinal stromal tumors in the United States from 2001\u20102015: a United States cancer statistics analysis of 50 states","volume":"11","author":"Patel N","year":"2019","journal-title":"Cureus."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000158"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018-0370-RS"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2010.0116"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2020.100812"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy095"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1737"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-018-0115-2"},{"issue":"6","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.ejso.2018.12.014","article-title":"A new nomogram for recurrence\u2010free survival prediction of gastrointestinal stromal tumors: comparison with current risk classification methods","volume":"45","author":"Chen T","year":"2019","journal-title":"Eur J Surg Oncol."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/adpa.2002.35741"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2002.120323"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24442"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2016.083"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24252"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24631"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02433.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i26.2806"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2013.08.001"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/EUS-D-20-00171"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4630"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.13050"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2007.00505.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.7889-21"},{"volume-title":"WHO Classification of Tumours. 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