{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:38:53Z","timestamp":1762609133784,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pancreatic cyst cytology evaluates for neoplastic mucin and epithelial grade. This study describes cytological features of low\u2010 and high\u2010grade mucinous neoplasms (MNs) using gastrointestinal contaminants for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Histologically confirmed pancreatic cystic neoplasms were reviewed by a panel of cytopathologists to identify which, among 26 selected cytologic features, correlate significantly with low\u2010 and high\u2010grade MN. A test for greater than or equal to four of eight high\u2010grade features (three\u2010dimensional architecture, high nuclear:cytoplasmic ratio, moderate nuclear membrane abnormalities, loss of nuclear polarity, hyperchromasia, &gt;4:1 nuclear size variation in one cluster, karyorrhexis, and necrosis) was assessed for identifying a high\u2010grade neoplasms. Additional characteristics of the cohort such as cyst fluid carcinoembryonic antigen results, molecular testing, Papanicolaou Society of Cytopathology classification, and select high\u2010risk clinical features are described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Endoscopic ultrasound fine\u2010needle aspirations from 134 MN and 17 serous cystadenomas containing gastrointestinal contaminants were included. The MN consisted of 112 (84%) intraductal papillary MNs (low\u2010grade\u00a0=\u00a069, 62%; high\u2010grade\u00a0=\u00a024, 21%; and invasive\u00a0=\u00a019, 17%) and mucinous cystic neoplasms (low\u2010grade\u00a0=\u00a020, 90%; high\u2010grade\u00a0=\u00a02, 10%). Half had greater than five clusters of epithelium for analysis. Compared with gastrointestinal contaminants, mucin from MN was thick and colloid\u2010like (40% vs. 6%, <jats:italic>p<\/jats:italic> &lt; .01), covered &gt;20% of the smear area (32% vs. none, <jats:italic>p<\/jats:italic> &lt; .01), and contained histiocytes (46% vs. 18%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04). Greater than or equal to four of eight select high\u2010grade features was present in 36% of high\u2010grade MN with sensitivity 37% and 98% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Colloid\u2010like features, &gt;20% of smear, and histiocytes correlated with MN. Testing for greater than or equal to four high\u2010grade features had low sensitivity and high specificity for high\u2010grade MN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22681","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T23:19:48Z","timestamp":1673997588000},"page":"325-336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Diagnostic features of low\u2010 and high\u2010grade mucinous neoplasms in pancreatic cyst FNA cytology"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6276-3968","authenticated-orcid":false,"given":"Carlie","family":"Sigel","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Jun","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narasimhan","family":"Agaram","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Sigel","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshan","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Pathology Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rema","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pari","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8876-4894","authenticated-orcid":false,"given":"Abha","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1007\/978-3-319-16589-9"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1002\/cncr.21838"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1002\/cncy.21344"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1002\/cncy.21806"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1002\/cncr.20052"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1309\/cepk542w38852lp8"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1002\/cncy.22514"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1002\/cncy.21657"},{"issue":"6","key":"e_1_2_8_10_1","first-page":"715","article-title":"Endoscopic ultrasound\u2010guided fine\u2010needle aspiration cytology in the diagnosis of intraductal papillary mucinous neoplasms of the pancreas. 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