{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:36:38Z","timestamp":1792816598481,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Digital cytology (DC) with artificial intelligence (AI) is a new approach. The authors compared DC with liquid\u2010based cytology (LBC) using computer assistance (CAS) in a retrospective, noninterventional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 1994 ThinPrep LBC slides (Hologic), which were previously analyzed in 2020 using an imaging system with CAS in routine cotesting for cytology\/human papillomavirus, were reviewed in a blinded mode using the Genius Digital Diagnostics System (Hologic). In 555 cases, a histology result was available. The slides were digitally scanned (volumetric scan) at 14 levels integrated into one. AI algorithms were used to present a gallery of six tiles each (containing objects of interest) in five categories. Six additional tile rows were available, from which the diagnoses were made. All cases with a mismatch between DC and imaging system results were reviewed by an additional cytopathologist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 86.56% of cases, a complete match between both systems was observed using the same cytology categories. When also considering the histology results, the match was 90.37%. In addition, when a cytology follow\u2010up and\/or a retrospective review was applied, the match reached 97.34%. In only 0.65% of cases was a major discrepancy observed (two grades of cytology or a low\u2010grade squamous intraepithelial lesion\/high\u2010grade squamous intraepithelial lesion [LSIL\/HSIL] shift), and none were identified by DC. Significantly more cases of higher severity (atypical squamous cells cannot exclude high grade [ASC\u2010H], high\u2010grade squamous intraepithelial lesion [HSIL]) were identified with DC, and its negative predictive value was higher. The screening time was significantly shorter with DC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>With the Genius system for DC, the sensitivity for HSIL+\/ASC\u2010H and the specificity for LSIL and HSIL were superior to LBC and CAS. Screening time was significantly lower.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncy.22695","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T13:30:40Z","timestamp":1681738240000},"page":"424-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Comparison of the Hologic Genius Digital Diagnostics System with the ThinPrep Imaging System\u2014A retrospective assessment"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4381-5675","authenticated-orcid":false,"given":"Hans","family":"Ikenberg","sequence":"first","affiliation":[{"name":"MVZ CytoMol  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Lieder","sequence":"additional","affiliation":[{"name":"Hologic Deutschland GmbH  Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Ahr","sequence":"additional","affiliation":[{"name":"MVZ CytoMol  Frankfurt Germany"},{"name":"Universit\u00e4tsfrauenklinik Frankfurt  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Natural and Economic Sciences Ulm University of Applied Sciences  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Sch\u00f6n","sequence":"additional","affiliation":[{"name":"BioTeSys GmbH  Esslingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjola","family":"Xhaja","sequence":"additional","affiliation":[{"name":"MVZ CytoMol  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization (WHO).Human Papillomavirus (HPV) and Cervical Cancer. WHO; 2022. Accessed March 21 2023.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/cervical\u2010cancer"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.86"},{"key":"e_1_2_9_4_1","unstructured":"Gemeinsamer Bundesausschuss.Tragende Gr\u00fcnde zum Beschluss des Gemeinsamen Bundesaus\u2010schusses \u00fcber eine \u00c4nderung der Krebsfr\u00fcherkennungs\u2010Richtlinie und eine \u00c4nderung der Richtlinie f\u00fcr organisierte Krebsfr\u00fcherkennungsprogramme: Programm zur Fr\u00fcherkennung von Zervixkarzinomen;2018. Gemeinsamer Bundesausschuss; 2020. Accessed March 21 2023.https:\/\/www.g\u2010ba.de\/downloads\/40\u2010268\u20105486\/2018\u201011\u201022_oKFE\u2010RL_Zervixkarzinom_TrG.pdf"},{"key":"e_1_2_9_5_1","volume-title":"Abkl\u00e4rungsdiagnostik f\u00fcr auff\u00e4llige Befunde im Rahmen der Richtlinie f\u00fcr organisierte Krebsfr\u00fcherkennungsprogramme (oKFE\u2010RL)","author":"Kassen\u00e4rztliche Bundesvereinigung (KVB)","year":"2020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7188.904"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23276"},{"key":"e_1_2_9_8_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program.SEER*Stat Database: Incidence\u2013SEER Research Data 9 Registries Public\u2010Use November 2018 Submission (1975\u20132016). SEER Program; 2017."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.5858\/2003\u2010127\u2010200\u2010CAOCPT"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.5858\/1999\u2010123\u20100817\u2010POAFBT"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20627"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23931"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000455775"},{"key":"e_1_2_9_14_1","volume-title":"Genius\u2122 Digital Diagnostics System Instructions for Use (AW\u201024823\u2010001_001_02)","author":"Hologic","year":"2021"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101886\u20103311"},{"key":"e_1_2_9_16_1","volume-title":"ThinPrep Imaging System Instructions for Use (MAN\u201008723\u2010001_001_02)","author":"Hologic","year":"2021"},{"key":"e_1_2_9_17_1","first-page":"88","volume-title":"Cytology. In: Pfister H, ed. Prophylaxis and Early Detection of HPV\u2010Related Neoplasm. Monographs in Virology","author":"Ikenberg H","year":"2012"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpi.jpi_96_20"}],"container-title":["Cancer Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.22695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T17:00:57Z","timestamp":1760288457000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncy.22695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/cncy.22695"],"URL":"https:\/\/doi.org\/10.1002\/cncy.22695","archive":["Portico"],"relation":{},"ISSN":["1934-662X","1934-6638"],"issn-type":[{"value":"1934-662X","type":"print"},{"value":"1934-6638","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,17]]},"assertion":[{"value":"2022-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}