{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T21:03:14Z","timestamp":1765486994648,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aims to assess the immediate risk of cervical precancers and cancers in women with atypical glandular cells (AGC) cytology, based on high\u2010risk human papillomavirus (hrHPV) genotypes and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted on 369 cases of AGC with immediate follow\u2010up biopsy results, including 299 AGC\u2010not otherwise specified (NOS) and 70 AGC\u2010favor neoplastic (FN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 369 AGC cases, 127 tested positive for hrHPV (34.4%). The predominant high\u2010risk type was other 11 genotypes (44.1%), followed by 16+ (29.1%), 18\/45+ (26.0%), and 16 and 18\/45 double\u2010positive (0.79%). Precancers and cancers were detected in 30.4% (112 of 369) and 9.8% (36 of 369) of cases, respectively. The HPV\u201018\/45+ group had notably higher adenocarcinoma in situ and adenocarcinoma (AIS+) prevalence compared to other 11 genotype groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001 and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001, respectively). The HPV\u201016+ group showed significantly higher high\u2010grade cervical squamous epithelial lesion and squamous cell carcinoma prevalence than other 11 genotype groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001 and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.017, respectively). Using 40\u2010year cutoff, older women had significantly higher prevalence of abnormal glandular lesion+\u00a0lesions (17.6% vs. 7.6%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005) and adenocarcinoma (AC) (12.4% vs. 2.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). Using 50\u2010year cutoff, older women had higher prevalence of squamous cell carcinoma (SCC) (3.3% vs. 0.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.042) and AC (15.2% vs. 5.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005). Subgroup analysis revealed that AGC\u2010FN women showed more severe cervical pathology than AGC\u2010NOS women (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AGC women have a significantly increased risk of cervical precancerous lesions and cancer. HPV genotyping and patient age factors need to be taken into consideration in the clinical management process of AGC patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22780","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T17:38:11Z","timestamp":1700588291000},"page":"119-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Correlation of immediate prevalence of cervical precancers and cancers with HPV genotype and age in women with atypical glandular cells cytology: A retrospective analysis of 369 cases"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5123-9183","authenticated-orcid":false,"given":"Xin","family":"Zhou","sequence":"first","affiliation":[{"name":"Departments of Pathology International Peace Maternity and Child Health Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Pathology Zhejiang University School of Medicine Women\u2019s Hospital  Hangzhou Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanrun","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology National Cancer Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Qin","sequence":"additional","affiliation":[{"name":"Carlson School of Chemistry and Biochemistry Clark University  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biology University at Albany  Albany New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Zhejiang University School of Medicine Women\u2019s Hospital  Hangzhou Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Pathology International Peace Maternity and Child Health Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2402-4774","authenticated-orcid":false,"given":"Feng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Departments of Pathology International Peace Maternity and Child Health Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Pathology Zhejiang University School of Medicine Women\u2019s Hospital  Hangzhou Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1002\/ijc.30609"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1016\/j.bpobgyn.2011.04.006"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1056\/nejmoa021641"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1002\/(sici)1096\u20109896(199909)189:1<12::aid\u2010path431>3.0.co;2\u2010f"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1002\/14651858.cd008587.pub2"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1038\/sj.bjc.6602915"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1309\/ajcptgd94evrsjcg"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.1007\/978-3-319-11074-5"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.1097\/01.aog.0000202401.29145.68"},{"doi-asserted-by":"publisher","key":"e_1_2_9_11_1","DOI":"10.1111\/j.1447\u20100756.2010.01387.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_12_1","DOI":"10.1016\/j.ejogrb.2009.07.007"},{"doi-asserted-by":"publisher","key":"e_1_2_9_13_1","DOI":"10.1097\/lgt.0b013e318287d329"},{"doi-asserted-by":"publisher","key":"e_1_2_9_14_1","DOI":"10.1097\/lgt.0000000000000525"},{"issue":"4","key":"e_1_2_9_15_1","first-page":"266","article-title":"Atypical glandular cells of undetermined significance. 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