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However, in most cases, these risk of malignancy estimates have not been based on high\u2010quality evidence and often may not be consider proper \u201crisks\u201d (because they have been estimated based on cross\u2010sectional studies). This commentary discusses the problems related to the data used to generate these risks. To make nongynecological cytopathology reporting more evidence\u2010based, large\u2010scale prospective cohort studies and randomized trials, in addition to high\u2010quality systematic reviews and meta\u2010analyses, should be performed.<\/jats:p>","DOI":"10.1002\/cncy.22787","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T06:24:02Z","timestamp":1703139842000},"page":"335-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Challenging the concept of \u201crisk of malignancy\u201d in cytology"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8625-2556","authenticated-orcid":false,"given":"Ilias P.","family":"Nikas","sequence":"first","affiliation":[{"name":"School of Medicine European University Cyprus  Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricella","family":"Souza da 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