{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:59:48Z","timestamp":1787504388677,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n DICER1<\/jats:italic>\n mutations, though infrequent, are encountered on preoperative molecular testing of indeterminate adult and pediatric thyroid fine\u2010needle aspiration (FNA) specimens. Yet, published cytomorphologic features of\n DICER1<\/jats:italic>\n \u2010altered thyroid lesions are limited. Cytomorphological features of\n DICER1<\/jats:italic>\n \u2010altered thyroid lesions were examined in a multipractice FNA cohort with clinical, radiological, and histologic data.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The cohort comprised 18\n DICER1<\/jats:italic>\n \u2010altered thyroid FNAs, with 14 having slides available and eight having corresponding surgical resections. Smears, ThinPrep, and formalin\u2010fixed cell block slides were reviewed and correlated with histology, when available. Clinical and radiologic data were obtained from the medical record.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Most\n DICER1<\/jats:italic>\n \u2010altered FNAs were classified as atypia of undetermined significance (94.4%).\n DICER1<\/jats:italic>\n mutations occurred in codons 1709 (50%), 1810 (27.8%), and 1813 (22.2%). One patient had an additional\n DICER1<\/jats:italic>\n p.D1822N variant in both of their FNAs. Lesions were often hypoechoic (35.3%) and solid (47.1%) on ultrasound. Notable cytomorphologic features include mixed but prominent microfollicular or crowded component, variable colloid, and insignificant nuclear atypia. On resection (\n n<\/jats:italic>\n \u00a0=\u00a010), histologic diagnoses ranged from benign follicular adenoma and low\u2010risk follicular thyroid carcinoma to high\u2010grade follicular\u2013derived nonanaplastic thyroid carcinoma. Subcapsular infarct\u2010type change was the most common histologic change. There was no evidence of recurrence or metastasis in eight patients on limited follow\u2010up.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n DICER1<\/jats:italic>\n \u2010altered thyroid lesions occurred frequently in young females and FNAs show RAS\u2010like cytomorphology including crowded, mixed macro\u2010\/microfollicular pattern, and bland nuclear features. On resection,\n DICER1<\/jats:italic>\n \u2010altered thyroid lesions include benign (50%), low\u2010risk lesions (30%), or high\u2010risk malignancies (20%).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cncy.22805","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T04:50:51Z","timestamp":1711169451000},"page":"359-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comprehensive evaluation of cytomorphologic, histologic, and molecular features of\n DICER1<\/i>\n \u2010altered thyroid lesions on FNA: A multipractice experience"],"prefix":"10.1002","volume":"132","author":[{"given":"Krisztina","family":"Lengyel","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Emory University Hospital Midtown Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Lubin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Emory University Hospital Midtown Atlanta Georgia USA"},{"name":"Winship Cancer Institute of Emory University Decatur Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Yu","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Emory University Hospital Midtown Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Sirotnikov","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Children\u2019s Healthcare of Atlanta Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangju","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Children\u2019s Healthcare of Atlanta Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Children\u2019s Healthcare of Atlanta Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0224-3167","authenticated-orcid":false,"given":"Qiuying","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Emory University Hospital Midtown Atlanta Georgia USA"},{"name":"Winship Cancer Institute of Emory University Decatur Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Magliocca","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Emory University Hospital Midtown Atlanta Georgia USA"},{"name":"Winship Cancer Institute of Emory University Decatur Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda M.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Emory University Hospital Midtown Atlanta Georgia USA"},{"name":"Winship Cancer Institute of Emory University Decatur Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald L.","family":"Sears","sequence":"additional","affiliation":[{"name":"Emory Saint Joseph Hospital Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghulam","family":"Ilyas","sequence":"additional","affiliation":[{"name":"Emory Johns Creek Hospital Johns Creek Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly B.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Children\u2019s Healthcare of Atlanta Atlanta Georgia 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