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Significant changes were made to the categorization of benign neoplasms, intraductal neoplasms, mucinous cystic neoplasms, and malignant neoplasms considered low grade. Benign neoplasms, such as serous cystadenoma, categorized as Neoplastic: benign in the PSC system, are categorized as Benign\/negative for malignancy in the WHO system. Pancreatic neuroendocrine tumor, solid\u2010pseudopapillary neoplasm, and gastrointestinal stromal tumor, categorized as Neoplastic: other in the PSC system, are categorized as Malignant in the WHO System in accord with their classification in the 5th edition WHO Classification of Digestive System Tumours (2019). The two new categories of Pancreaticobiliary Neoplasm Low\u2010risk\/grade and Pancreaticobiliary Neoplasm High\u2010risk\/grade are mostly limited to intraductal neoplasms and mucinous cystic neoplasms. Low\u2010risk\/grade lesions are mucinous cysts, with or without low\u2010grade epithelial atypia. High\u2010risk\/grade lesions contain neoplastic epithelium with high\u2010grade epithelial atypia. Correlation with clinical, imaging, and ancillary studies remains a key tenet. The sections for each entity are written to highlight key cytopathological features and cytopathological differential diagnoses with the pathologist working in low resource setting in mind. Each section also includes the most pertinent ancillary studies useful for the differential diagnosis. Sample reports are provided for each category. Finally, the book provides a separate section with risk of malignancy and management recommendations for each category to facilitate decision\u2010making for clinicians.<\/jats:p>","DOI":"10.1002\/cncy.22806","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T13:11:11Z","timestamp":1715001071000},"page":"396-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The World Health Organization Reporting System for Pancreaticobiliary Cytopathology: Overview and Summary"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7668-2748","authenticated-orcid":false,"given":"Barbara A.","family":"Centeno","sequence":"first","affiliation":[{"name":"Department of Pathology Moffitt Cancer Center  Tampa Florida 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