{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:31:28Z","timestamp":1790796688098,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) recommends an upper limit of 10% for atypia of undetermined significance (AUS). Recent data suggest that this category might be overused when the rate of cases with molecular positive results is low. As a quality metric, the AUS and positive call rates for this facility\u2019s cytology laboratory and each cytopathologist (CP) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of all thyroid cytology cases in a 4.5\u2010year period was performed. Cases were stratified by TBSRTC, and molecular testing results were collected for indeterminate categories. The AUS rate was calculated for each CP and the laboratory. The molecular positive call rate (PCR) was calculated with and without the addition of currently negative to the positive results obtained from the ThyroSeq report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 7535 cases were classified as nondiagnostic, 7.6%; benign, 69%; AUS, 17.5%; follicular neoplasm\/suspicious for follicular neoplasm, 1.4%; suspicious for malignancy, 0.7%; and malignant, 3.8%. The AUS rate for each CP ranged from 9.9% to 36.8%. The overall PCR was 24% (range, 13%\u201335.6% per CP). When including cases with currently negative results, the PCR increased to 35.5% for the cytology laboratory (range, 13%\u201342.6% per CP). Comparison analysis indicates a combination of overcalling benign cases and, less frequently, undercalling of higher TBSRTC category cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The AUS rate in the context of PCR is a useful metric to assess cytology laboratory and cytopathologists\u2019 performance. Continuous feedback on this metric could help improve the overall quality of reporting thyroid cytology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncy.22821","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T22:03:44Z","timestamp":1712700224000},"page":"481-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Atypia of undetermined significance and ThyroSeq v3\u2013positive call rates as quality control metrics for cytology laboratory performance"],"prefix":"10.1002","volume":"132","author":[{"given":"Odille","family":"Mejia\u2010Mejia","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Bravo\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"CES University School of Medicine  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Sanchez\u2010Avila","sequence":"additional","affiliation":[{"name":"Jackson Memorial Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8665-312X","authenticated-orcid":false,"given":"Youley","family":"Tjendra","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Miller School of Medicine University of Miami  Miami Florida USA"},{"name":"Sylvester Comprehensive Cancer Center Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Santoscoy","sequence":"additional","affiliation":[{"name":"Jackson Memorial Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Drews\u2010Elger","sequence":"additional","affiliation":[{"name":"Jackson Memorial Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqin","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Miller School of Medicine University of Miami  Miami Florida USA"},{"name":"Sylvester Comprehensive Cancer Center Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo","family":"Arias\u2010Abad","sequence":"additional","affiliation":[{"name":"Departamento de Matematicas Universidad Nacional de Colombia  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Miller School of Medicine University of Miami  Miami Florida USA"},{"name":"Sylvester Comprehensive Cancer Center Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Garcia\u2010Buitrago","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Miller School of Medicine University of Miami  Miami Florida USA"},{"name":"Sylvester Comprehensive Cancer Center Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Nadji","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Miller School of Medicine University of Miami  Miami Florida USA"},{"name":"Sylvester Comprehensive Cancer Center Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merce","family":"Jorda","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Miller School of Medicine University of Miami  Miami Florida USA"},{"name":"Sylvester Comprehensive Cancer Center Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8385-2748","authenticated-orcid":false,"given":"Jaylou M.","family":"Velez\u2010Torres","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Miller School of Medicine University of Miami  Miami Florida USA"},{"name":"Sylvester Comprehensive Cancer Center Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Ruiz\u2010Cordero","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Miller School of Medicine University of Miami  Miami Florida USA"},{"name":"Sylvester Comprehensive Cancer Center Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20830"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2023.0141"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4274\/2017.26.suppl.04"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2021.10.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0500"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2021.11.002"},{"key":"e_1_2_8_8_1","unstructured":"NCCN Clinical Practice Guideline.Thyroid carcinoma;2023. Version 1.2024 \u2014 February 28."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2023.09.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20192"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22542"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0317"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23805"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486779"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/1742\u20106413.139725"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24193"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463\u2010021\u201000530\u20100"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21754"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2021.07.001"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.649522"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.4616"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22362"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22617"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4521984"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2020.03.004"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad220"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23915"}],"container-title":["Cancer Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.22821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:45:12Z","timestamp":1760265912000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncy.22821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,9]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/cncy.22821"],"URL":"https:\/\/doi.org\/10.1002\/cncy.22821","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.01.24.24301631","asserted-by":"object"}]},"ISSN":["1934-662X","1934-6638"],"issn-type":[{"value":"1934-662X","type":"print"},{"value":"1934-6638","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,9]]},"assertion":[{"value":"2024-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}