{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:15:31Z","timestamp":1791011731025,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study conducts the first meta\u2010analysis to assess the aggregated risk of malignancy associated with each category of the International System for Reporting Serous Fluid Cytopathology (ISRSFC) for reporting serous effusion cytology, while also evaluating diagnostic accuracy. PubMed\/MEDLINE and Embase were systematically searched using the keywords \u201c(pleural, peritoneal, and pericardial effusions) AND (serous effusion cytology) OR (International System for Reporting Serous Fluid Cytopathology)\u201d. Articles underwent risk of bias assessment using the QUADAS\u20102 tool. After excluding inadequate samples, a meta\u2010analysis determined sensitivity and specificity for different cutoff points, including \"atypical considered positive,\" \"suspicious of malignancy considered positive,\" and \"malignant considered positive.\" Summary receiver operating characteristic curves assessed diagnostic accuracy, and the diagnostic odds ratio was pooled. Sixteen retrospective cross\u2010sectional studies, totaling 19,128 cases, were included. Sensitivity and specificity for the \u201catypical and higher risk categories\u201d considered positive were 77% (95% confidence interval [CI], 68%\u201384%) and 95% (95% CI, 93%\u201397%) respectively. For the \u201csuspicious for malignancy and higher risk categories\u201d considered positive, sensitivity and specificity were 57% (95% CI, 49%\u201365%) and 100% (95% CI, 99%\u2013100%) respectively. Sensitivity and specificity for the \u201cmalignant\u201d category considered positive for malignancy were 70% (95% CI, 60%\u201377%) and 99% (95% CI, 98%\u201399%), respectively. The pooled area under the curve ranged from 85% to 89.5% for each cutoff. This meta\u2010analysis underscores the ISRSFC's accuracy in reporting serous fluid cytology. It emphasizes the diagnostic importance of the \"suspicious\" and \"malignant\" categories in identifying malignancy, and the role of the \"benign\" category in ruling out malignancy.<\/jats:p>","DOI":"10.1002\/cncy.22822","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T12:39:55Z","timestamp":1713011995000},"page":"609-620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Diagnostic accuracy of International System for Reporting Serous Fluid Cytopathology: A systematic review and meta\u2010analysis in malignancy diagnosis"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4630-016X","authenticated-orcid":false,"given":"Sana","family":"Ahuja","sequence":"first","affiliation":[{"name":"Department of Pathology Vardhman Mahavir Medical College and Safdarjung Hospital  New Delhi 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