{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:24:52Z","timestamp":1791408292676,"version":"4.3.3"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The 2023 Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) divides AUS diagnoses into two major subcategories: atypia of undetermined significance (AUS) nuclear atypia (AUS\u2010N) and other (AUS\u2010O). This study aims to compare the histological outcome and malignant rate of pediatric AUS thyroid nodules classified into AUS\u2010N and AUS\u2010O subcategories.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A search of our institutional electronic pathology database for the period from January 2012 to July 2023 was conducted to identify pediatric (&lt;21 years old) thyroid nodules that were interpreted as AUS and subsequently had surgery. Cases were further divided into AUS\u2010N and AUS\u2010O subcategories. Results of follow\u2010up surgical resections were collected. The malignant rate was calculated and compared between AUS\u2010N and AUS\u2010O groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study identified 62 thyroid nodules from 58 pediatric patients. Among these nodules, 29 and 33 were subcategorized as AUS\u2010N and AUS\u2010O, respectively. Both groups exhibited a female predominance and displayed a similar nodule size distribution. Histological analysis revealed 15 carcinomas in AUS\u2010N nodules, including 11 cases of classic papillary thyroid carcinoma (PTC) and four cases of follicular type of PTC. In contrast, in the AUS\u2010O group, a total of five carcinomas were documented, including two PTCs and three oncocytic thyroid carcinomas. Notably, the malignant rate of AUS\u2010N nodules (52%) is significantly higher than that of AUS\u2010O nodules (15%) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In pediatric AUS thyroid nodules, the malignant risk in AUS\u2010N is significantly higher than that in AUS\u2010O. These findings may guide more appropriate clinical triage and\/or improve management of pediatric patients with AUS thyroid nodules.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.22831","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T13:39:26Z","timestamp":1716298766000},"page":"564-568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Malignant risk of pediatric Bethesda category III thyroid nodules subcategorized by nuclear atypia and other: A single institution experience"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6189-435X","authenticated-orcid":false,"given":"Xiaobing","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Pathology University of Michigan\u2010Michigan Medicine  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1768-3472","authenticated-orcid":false,"given":"Xin","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan\u2010Michigan Medicine  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Smola","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan\u2010Michigan Medicine  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer","family":"Heider","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan\u2010Michigan Medicine  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21884"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0460"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018\u20100596\u2010OA"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2017.09.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618\u2010021\u201001526\u20103"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22625"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2023.05.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24266"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30360"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000513066"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463\u2010021\u201000530\u20100"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0728"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0059"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333232"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2023.10.001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22544"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28300"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1093526619866584"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2022.0239"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21933"}],"container-title":["Cancer Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.22831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:50:11Z","timestamp":1760287811000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncy.22831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,21]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/cncy.22831"],"URL":"https:\/\/doi.org\/10.1002\/cncy.22831","archive":["Portico"],"relation":{},"ISSN":["1934-662X","1934-6638"],"issn-type":[{"value":"1934-662X","type":"print"},{"value":"1934-6638","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,21]]},"assertion":[{"value":"2024-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}