{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:04:10Z","timestamp":1788627850812,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K06941"],"award-info":[{"award-number":["22K06941"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H02694"],"award-info":[{"award-number":["23H02694"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A standardized reporting system for bone and soft tissue tumor cytopathology has not yet been established. The objective of this study was to explore the potential utility of a classification modified from the Milan System for Salivary Gland Cytopathology and compared it with the upcoming World Health Organization (WHO) system for fine\u2010needle aspiration of soft tissue lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The authors reviewed 285 cytology cases of bone\/joint (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0173) and soft tissue (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0112) lesions, scoring each within diagnostic categories. The results were compared with histologic diagnoses and the risk of malignancy (ROM) for each category, and diagnostic reliability was analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All 285 cases were successfully classified into one of the following categories: nondiagnostic (6.3%), non\u2010neoplastic (11.9%), atypia of uncertain significance (11.9%), benign neoplasm (5.6%), bone and soft tissue neoplasm of uncertain malignant potential (25.3%), suspicious for malignancy (1.4%), and malignant (37.5%). The ROM was 44.4% (eight of \/18 cases) in nondiagnostic, 0% (zero of 34 cases) in non\u2010neoplastic, 32.4% (11 of 34 cases) in atypia of uncertain significance, 0% (zero of 16 cases) in benign neoplasm, 16.7% (12 of 72 cases) in bone and soft tissue neoplasm of uncertain malignant potential, 75.0% (three of four cases) in suspicious for malignancy, and 100% (107 of 107 cases) in malignant categories. Using the WHO system, the proportion and ROM of the benign category (non\u2010neoplastic and benign neoplasm) was 17.5% and 0%, respectively. Among benign and malignant lesions, the diagnostic accuracy, sensitivity, and specificity for detecting malignancy were 99.4%, 100%, and 98.0%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The modified Milan system as well as the WHO system may be a useful cytopathologic classification tool for both bone and soft tissue lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncy.22888","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T12:51:10Z","timestamp":1722257470000},"page":"696-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reappraisal of bone and soft tissue cytopathology classification using the modified Milan system"],"prefix":"10.1002","volume":"132","author":[{"given":"Masaki","family":"Naka","sequence":"first","affiliation":[{"name":"Division of Diagnostic Pathology Kyushu University Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9148-6445","authenticated-orcid":false,"given":"Hidetaka","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Kyushu University Hospital  Fukuoka Japan"},{"name":"Department of Anatomic Pathology Pathological Sciences Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Department of Pathology and Oncology Graduate School of Medicine Dentistry and Pharmaceutical Science Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Kohashi","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Pathological Sciences Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Department of Pathology Graduate School of Medicine Osaka Metropolitan University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Kyushu University Hospital  Fukuoka Japan"},{"name":"Department of Anatomic Pathology Pathological Sciences Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Mori","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Kyushu University Hospital  Fukuoka Japan"},{"name":"Department of Anatomic Pathology Pathological Sciences Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miwako","family":"Nogami","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Kyushu University Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Ookubo","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Kyushu University Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayoko","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Okinawa Kyodo Hospital  Naha Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Motoi","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinao","family":"Oda","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Kyushu University Hospital  Fukuoka Japan"},{"name":"Department of Anatomic Pathology Pathological Sciences Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2022.151936"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03430070079034"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1309\/ajcpphlwmi3jv4la"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446270"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-26662-1"},{"key":"e_1_2_8_7_1","article-title":"Symposia 6\u2014The WHO System for Reporting Soft Tissue Cytopathology: The Rationale, Structure, Categories and Application in Routine Reporting","author":"American Society of Cytopathology (ASC)","year":"2023","journal-title":"American Society of Cytopathology"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12914"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000531051"},{"key":"e_1_2_8_10_1","volume-title":"WHO Classification of Tumours Soft Tissue and Bone Tumours","author":"The WHO Classification of Tumours Editorial Board","year":"2020"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22505"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097\u20100142(20000225)90:1<47::aid\u2010cncr7>3.3.co;2\u2010k"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20058"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23122"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2010009\u20101100\u20107"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1309\/yn14\u2010k8u4\u20105flj\u2010dgje"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.5858\/2004\u2010128\u2010759\u2010concba"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0956\u20105507.2003.00102.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1309\/ajcpbwjp3cg6jzka"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10200"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(20001025)90:5<292::aid\u2010cncr5>3.0.co;2\u20108"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.25017"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.25259\/cytojournal_2_2023"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.13270"}],"container-title":["Cancer Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.22888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T18:50:38Z","timestamp":1760295038000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncy.22888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,29]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/cncy.22888"],"URL":"https:\/\/doi.org\/10.1002\/cncy.22888","archive":["Portico"],"relation":{},"ISSN":["1934-662X","1934-6638"],"issn-type":[{"value":"1934-662X","type":"print"},{"value":"1934-6638","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,29]]},"assertion":[{"value":"2024-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}