{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:36:40Z","timestamp":1792816600761,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Artificial intelligence (AI)\u2013based systems are transforming cytopathology practice. The aim of this study was to evaluate the sensitivity of high\u2010grade squamous intraepithelial lesion (HSIL) Papanicolaou (Pap) diagnosis assisted by the Hologic Genius Digital Diagnostics System (GDDS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A validation study was performed with 890 ThinPrep Pap tests with the GDDS independently. From this set, a subset of 183 cases originally interpreted as HSIL confirmed histologically were included in this study. The sensitivity for detecting HSIL by three cytopathologists was calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most HSIL cases were classified as atypical glandular cell\/atypical squamous cell\u2013high grade not excluded (AGC\/ASC\u2010H) and above by all cytopathologists. Of these cases, 11.5% were classified as low\u2010grade squamous intraepithelial lesion (LSIL) by pathologist A (P\u2010A), 6% by pathologist B (P\u2010B), and 5.5% by pathologist C (P\u2010C); 3.8%, 2.7%, and 1.6% of these cases were classified as atypical squamous cell of unknown significance (ASC\u2010US) by P\u2010A, P\u2010B, and P\u2010C, respectively. The sensitivity for detection of cervical intraepithelial neoplasia 2 and above (CIN2+) lesions was 100% if ASC\u2010US and above (ASC\u2010US+) abnormalities were counted among all three pathologists. The sensitivity for detection of CIN2+ lesions was 84.7%, 91.3%, and 92.9% by P\u2010A, P\u2010B, and P\u2010C, respectively, for ASC\u2010H and above abnormalities. The Kendall W coefficient was 0.722, which indicated strong agreement between all pathologists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>New\u2010generation AI\u2010assisted Pap test screening systems such as the GDDS have the potential to transform cytology practice. In this study, the GDDS aided in interpreting HSIL in ThinPrep Pap tests, with good sensitivity and agreement between the pathologists who interacted with this system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncy.22918","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T04:44:46Z","timestamp":1730781886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Analysis of the sensitivity of high\u2010grade squamous intraepithelial lesion Pap diagnosis and interobserver variability with the Hologic Genius Digital Diagnostics System"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6472-732X","authenticated-orcid":false,"given":"Lakshmi","family":"Harinath","sequence":"first","affiliation":[{"name":"Department of Pathology UPMC Magee\u2010Womens Hospital University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Elishaev","sequence":"additional","affiliation":[{"name":"Department of Pathology UPMC Magee\u2010Womens Hospital University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonee","family":"Matsko","sequence":"additional","affiliation":[{"name":"Department of Pathology UPMC Magee\u2010Womens Hospital University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Colaizzi","sequence":"additional","affiliation":[{"name":"Department of Pathology UPMC Magee\u2010Womens Hospital University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Wharton","sequence":"additional","affiliation":[{"name":"Department of Pathology UPMC Magee\u2010Womens Hospital University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Bhargava","sequence":"additional","affiliation":[{"name":"Department of Pathology UPMC Magee\u2010Womens Hospital University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8182-5503","authenticated-orcid":false,"given":"Liron","family":"Pantanowitz","sequence":"additional","affiliation":[{"name":"Department of Pathology UPMC Magee\u2010Womens Hospital University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology UPMC Magee\u2010Womens Hospital University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"2024 Cervical Cancer Education and Outreach resource Guide. Maryland Department of Health center for cancer prevention and control. Accessed October 17 2024.https:\/\/health.maryland.gov\/phpa\/cancer\/SharedDocuments\/2024CervicalEducationandOutreachResourceGuide.pdf"},{"key":"e_1_2_7_3_1","unstructured":"Cervical Cancer. World Health Organization. Accessed October 17 2024.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/cervical\u2010cancer"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0029\u20107844(97)00695\u20109"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11380"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2024.100486"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22561"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpi.jpi_96_20"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101886\u20103311"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100186"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/1742\u20106413.54917"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508629"},{"key":"e_1_2_7_13_1","volume-title":"Hologic ThinPrep Operator\u2019s Manual"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1309\/agb1\u2010mj9h\u20105n43\u2010megx"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22695"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.5858\/1999\u2010123\u20100817\u2010poafbt"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20627"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23931"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2018.05.034"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000455775"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24213"},{"key":"e_1_2_7_22_1","unstructured":"SureView\u2122 Cervical Cytology System.Techcyte. Accessed September 19 2024.https:\/\/techcyte.com\/products\/sureview\/"},{"key":"e_1_2_7_23_1","volume-title":"Genius Digital Diagnostics System with the Genius Cervical AI Algorithm, Instructions for Use"},{"key":"e_1_2_7_24_1","volume-title":"Genius\u2122 Digital Diagnostics System"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10278\u2010023\u201000821\u20100"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2023.11.006"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201023913\u20103"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3296"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2023.11.005"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015\u20100446\u2010cp"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpi.2024.100391"}],"container-title":["Cancer Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.22918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:16:44Z","timestamp":1760300204000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncy.22918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,5]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/cncy.22918"],"URL":"https:\/\/doi.org\/10.1002\/cncy.22918","archive":["Portico"],"relation":{},"ISSN":["1934-662X","1934-6638"],"issn-type":[{"value":"1934-662X","type":"print"},{"value":"1934-6638","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,5]]},"assertion":[{"value":"2024-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22918"}}