{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:15:52Z","timestamp":1784042152837,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Soft tissue and bone tumors of the salivary gland were compared using classic 4\u2010tier, Milan System for Reporting Salivary Gland Cytopathology (MSRSGC), and the International Academy of Cytology\u2010International Agency for Research on Cancer\u2010World Health Organization (IAC\u2013IARC\u2013WHO) Reporting System for Soft Tissue Cytopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The authors retrospectively analyzed 2219 salivary gland fine\u2010needle aspiration (FNA) samples collected at the Institut Curie in Paris between 1954 and 2022. A total of 86 cases (3.9%) were identified as soft tissue and bone tumors, with histological follow\u2010up in 63 cases (73%). Cytology was classified according to the classic European 4\u2010tier system, the MSRSGC, and the IAC\u2013IARC\u2013WHO System.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>According to the MSRSGC, eight cases were classified as nonneoplastic, 30 as benign, one as salivary gland neoplasm of uncertain malignant potential, five as suspicious for malignancy, and 42 as malignant. Benign or malignant nature was accurately assessed in 78 cases (90.7%), with exact histologic\u2010cytologic concordance in 51 cases (59.3%). FNA correctly identified 42 of 44 malignant tumors (95.5%), with exact diagnostic matches in 30 cases (68.2%). The MSRSGC achieved 88.3% overall accuracy, 93.6% sensitivity, and 82.7% specificity. Risk of malignancy (ROM) was comparable for malignant tumors across the classic European system, the MSRSGC, and the IAC\u2013IARC\u2013WHO System, with minor discrepancies observed in benign and indeterminate categories. No cases were assigned as nondiagnostic, atypia of undetermined significance, atypical.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite their rarity, soft tissue and bone tumors of the salivary gland can be effectively diagnosed using the MSRSGC, with a high accuracy achieved for malignant cases. Minor discrepancies in ROMs were observed between specific categories of the classic European system, the MSRSGC, and the IAC\u2013IARC\u2013WHO System.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncy.70040","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T16:39:53Z","timestamp":1755707993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Application of the Milan and IAC\u2013IARC\u2013WHO Systems in diagnosing soft tissue and bone tumors of the salivary glands: The Institut Curie experience"],"prefix":"10.1002","volume":"133","author":[{"given":"Adam","family":"Kowalewski","sequence":"first","affiliation":[{"name":"Department of Pathology and Theranostics Institut Curie PSL University  Paris France"},{"name":"Department of Tumor Pathology Oncology Centre Prof. Franciszek \u0141ukaszczyk Memorial Hospital  Bydgoszcz Poland"},{"name":"Faculty of Medicine Bydgoszcz University of Science and Technology  Bydgoszcz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u0119drzej","family":"Borowczak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Bydgoszcz University of Science and Technology  Bydgoszcz Poland"},{"name":"Clinical Department of Oncology Oncology Centre Prof. Franciszek \u0141ukaszczyk Memorial Hospital  Bydgoszcz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9 J.","family":"Brisse","sequence":"additional","affiliation":[{"name":"Department of Radiology Institut Curie PSL University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Choussy","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Institut Curie PSL University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9706-7241","authenticated-orcid":false,"given":"Jerzy","family":"Klijanienko","sequence":"additional","affiliation":[{"name":"Department of Pathology and Theranostics Institut Curie PSL University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-26662-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22040"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22556"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.25340"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22897"},{"key":"e_1_2_8_7_1","first-page":"375","volume-title":"Atlas of Tumor Pathology. 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