{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T18:08:18Z","timestamp":1764698898358,"version":"3.45.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A comparative analysis of the International Academy of Cytology\u2013International Agency for Research on Cancer\u2013World Health Organization Reporting System for Head and Neck Cytopathology (WHO) and the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 2218 salivary gland fine\u2010needle aspiration samples collected at the Institut Curie, Paris (1954\u20132022) were evaluated, with 1356 having histological follow\u2010up. Samples were classified according to the MSRSGC (nondiagnostic [ND], nonneoplastic [NN], atypia of undetermined significance [AUS], benign neoplasm [BN], salivary gland neoplasm of uncertain malignant potential [SUMP], suspicious for malignancy [SM], and malignant [M]) and the WHO system (insufficient\/inadequate\/nondiagnostic, benign, atypical, neoplasm of uncertain malignant potential [NUMP], suspicious for malignancy [SM], and malignant [M]). The risk of malignancy (ROM) was calculated for each category, and diagnostic performance metrics were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the MSRSGC, the ROM was ND, 50% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02); NN, 16.8% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0149); AUS (no cases); BN, 4.3% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0514); SUMP, 50% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02); SM, 56.1% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a066); and M, 98.2% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0623). In the WHO system, the ROM was insufficient\/inadequate\/nondiagnostic, 50% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02); benign, 7.1% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0663); atypical (no cases); NUMP, 50% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02); SM, 56.1% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a066); and M, 98.2% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0623). The WHO\u2019s \u201cbenign\u201d category, which combines NN and BN, balanced the NN\u2019s higher ROM (16.8%) and BN\u2019s lower ROM (4.3%) into 7.1%. Excluding the ND and SUMP\/NUMP categories, both systems demonstrated high diagnostic performance: sensitivity, 93.3%; specificity, 93.9%; positive predictive value, 94.2%; and negative predictive value, 92.9%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both systems effectively identify malignancy. The WHO system\u2019s merger of NN and BN into the benign category streamlines reporting and reduces variability, although it may mask clinically significant differences between nonneoplastic and benign neoplastic lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncy.70041","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T15:59:52Z","timestamp":1756137592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative analysis of the World Health Organization Reporting System for Head and Neck Cytopathology and the Milan System for Reporting Salivary Gland Cytopathology"],"prefix":"10.1002","volume":"133","author":[{"given":"Adam","family":"Kowalewski","sequence":"first","affiliation":[{"name":"Department of Pathology and Theranostics Institut Curie PSL University  Paris France"},{"name":"Department of Tumor Pathology Oncology Centre Prof. Franciszek \u0141ukaszczyk Memorial Hospital  Bydgoszcz Poland"},{"name":"Faculty of Medicine Bydgoszcz University of Science and Technology  Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u0119drzej","family":"Borowczak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Bydgoszcz University of Science and Technology  Bydgoszcz Poland"},{"name":"Clinical Department of Oncology Oncology Centre Prof. Franciszek \u0141ukaszczyk Memorial Hospital  Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Choussy","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Institut Curie PSL University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Lesnik","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Institut Curie PSL University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Badois","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Institut Curie PSL University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9706-7241","authenticated-orcid":false,"given":"Jerzy","family":"Klijanienko","sequence":"additional","affiliation":[{"name":"Department of Pathology and Theranostics Institut Curie PSL University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1007\/978-3-319-71285-7"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1002\/cncy.22040"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1007\/s10147\u2010019\u201001411\u20103"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1002\/cncy.22604"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1111\/jop.13229"},{"key":"e_1_2_8_7_1","first-page":"1","article-title":"Salivary gland tumours","volume":"15","author":"Klijanienko J","year":"2000","journal-title":"Monogr Clin Cytol"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1007\/978-3-031-67675-8"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1007\/978-3-319-61027-6"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1111\/cyt.13331"},{"volume-title":"WHO Classification of Head and Neck Tumours","year":"2024","author":"UK Government","key":"e_1_2_8_11_1"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1002\/9780470947821"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.1002\/dc.24350"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1159\/000530342"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1093\/ajcp\/aqz006"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.1002\/cncy.22532"},{"doi-asserted-by":"publisher","key":"e_1_2_8_17_1","DOI":"10.4103\/joc.joc_165_18"},{"doi-asserted-by":"publisher","key":"e_1_2_8_18_1","DOI":"10.1002\/cncy.21710"},{"doi-asserted-by":"publisher","key":"e_1_2_8_19_1","DOI":"10.1002\/dc.24097"},{"doi-asserted-by":"publisher","key":"e_1_2_8_20_1","DOI":"10.1002\/dc.24536"},{"doi-asserted-by":"publisher","key":"e_1_2_8_21_1","DOI":"10.1002\/dc.23716"},{"doi-asserted-by":"publisher","key":"e_1_2_8_22_1","DOI":"10.1016\/j.jasc.2023.08.004"},{"doi-asserted-by":"publisher","key":"e_1_2_8_23_1","DOI":"10.1002\/lary.26764"},{"doi-asserted-by":"publisher","key":"e_1_2_8_24_1","DOI":"10.1111\/cyt.13038"},{"doi-asserted-by":"publisher","key":"e_1_2_8_25_1","DOI":"10.1177\/20363613241242397"},{"doi-asserted-by":"publisher","key":"e_1_2_8_26_1","DOI":"10.4103\/0970\u20109371.155226"},{"doi-asserted-by":"publisher","key":"e_1_2_8_27_1","DOI":"10.1002\/(sici)1097\u20100142(19980825)84:4<231::aid\u2010cncr8>3.0.co;2\u2010p"},{"doi-asserted-by":"publisher","key":"e_1_2_8_28_1","DOI":"10.1002\/cncy.22016"},{"doi-asserted-by":"publisher","key":"e_1_2_8_29_1","DOI":"10.1002\/dc.25109"}],"container-title":["Cancer Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.70041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T07:39:48Z","timestamp":1762933188000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncy.70041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,25]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/cncy.70041"],"URL":"https:\/\/doi.org\/10.1002\/cncy.70041","archive":["Portico"],"relation":{},"ISSN":["1934-662X","1934-6638"],"issn-type":[{"type":"print","value":"1934-662X"},{"type":"electronic","value":"1934-6638"}],"subject":[],"published":{"date-parts":[[2025,8,25]]},"assertion":[{"value":"2025-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70041"}}