{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:07:11Z","timestamp":1788858431636,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Mutations in\n                      <jats:italic>DICER1<\/jats:italic>\n                      are uncommon, poorly understood, and infrequently found in thyroid nodules.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The objective of this study was to investigate category III\/IV thyroid nodules according to The Bethesda System for Reporting Thyroid Cytopathology with\n                      <jats:italic>DICER1<\/jats:italic>\n                      gene mutations detected in fine\u2010needle aspiration cytology samples using ThyroSeq v3 molecular testing, with a focus on an exploration of the clinical and histopathologic outcomes of these nodules. In this multicenter study spanning more than 6 years, nodules were retrospectively analyzed for patient demographics, clinical course, cytologic features, and histopathology, where available.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 88 patients with somatic\n                      <jats:italic>DICER1<\/jats:italic>\n                      mutations were included, with a mean age of 39.6 years and a female predominance. All mutations were in the somatic hotspot region, most commonly at the codon 5437 site. Most excised nodules showed benign histologic features (65.9%). Interestingly, the rate of malignancy was higher in this cohort compared with that in the national average.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>DICER1<\/jats:italic>\n                      mutations appear to confer a higher risk of malignancy, but are not associated with any specific cytological or histopathological distinguishing features.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncy.70045","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T09:57:22Z","timestamp":1757671042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>DICER1<\/i>\n                    mutations in Bethesda III\/IV thyroid cytology samples: A multicenter observational study"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5459-5384","authenticated-orcid":false,"given":"Afreen","family":"Karimkhan","sequence":"first","affiliation":[{"name":"Department of Pathology New York University Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pathology New York University Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7056-0212","authenticated-orcid":false,"given":"DeAnna","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Pathology Rutgers Robert Wood Johnson Medical School  New Brunswick New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Wald","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical College  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Hodak","sequence":"additional","affiliation":[{"name":"Department of Pathology New York University Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Givi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Memorial Sloan Kettering Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Khader","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical College  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8182-5503","authenticated-orcid":false,"given":"Liron","family":"Pantanowitz","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh 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