{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:45:32Z","timestamp":1792053932745,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The objective of the recently published\n                    <jats:italic>World Health Organization Reporting System for Lymph Node, Spleen, and Thymus Cytopathology<\/jats:italic>\n                    (WHO system) is to standardize the diagnostic approach to fine\u2010needle aspiration biopsies of hematolymphoid tissues. By categorizing specimens into five diagnostic groups\u2014inadequate\/insufficient\/nondiagnostic, benign, atypical, suspicious for malignancy, and malignant\u2014the system provides a structured framework that enhances diagnostic clarity and facilitates communication between cytopathologists and clinicians. Each category is associated with a defined risk of malignancy, supporting informed clinical decision making regarding further diagnostic workup. Accurate categorization requires the integration of cytomorphologic features and clinical context, and final and specific diagnoses often require ancillary techniques such as flow cytometry, immunocytochemistry, in situ hybridization, and molecular diagnostics. To assist cytopathologists, especially those less familiar with hematolymphoid neoplasms, the WHO system incorporates a pattern\u2010based diagnostic approach. Four cytopathologic patterns\u2014mixed lymphoid cell; predominantly small\/intermediate cell; predominantly large\/pleomorphic\/blastic cell; and single, very large, atypical cell\u2014serve as guides to narrow down differential diagnoses. However, interpretation can be challenging because of overlapping features, variable inflammatory backgrounds, and limited sample material. This review provides a brief overview of the WHO system and its application to hematolymphoid proliferations, emphasizing the importance of clinical correlation and the use of relevant ancillary techniques. It then provides in\u2010depth discussion of the pattern\u2010based approach to diagnosing hematolymphoid neoplasms on cytopathology. It highlights the strengths and limitations of cytopathologic evaluation in hematolymphoid neoplasms and provides practical insights for applying the WHO system in routine practice.\n                  <\/jats:p>","DOI":"10.1002\/cncy.70066","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:58:31Z","timestamp":1766487511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Practical implications of the World Health Organization Reporting System for Lymph Node, Spleen, and Thymus Cytopathology: Categories and ancillary testing for subtyping of hematolymphoid tumors on FNA biopsy cytopathology using a pattern\u2010based approach"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2342-1679","authenticated-orcid":false,"given":"Mats","family":"Ehinger","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Division of Pathology Faculty of Medicine Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Calaminici","sequence":"additional","affiliation":[{"name":"Cellular Pathology Department Barts Health National Health Service Trust and Barts Cancer Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immacolata","family":"Cozzolino","sequence":"additional","affiliation":[{"name":"Pathology Unit Luigi Vanvitelli University Hospital  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7358-5925","authenticated-orcid":false,"given":"Pio","family":"Zeppa","sequence":"additional","affiliation":[{"name":"Pathology Unit San Giovanni di Dio e Ruggi d'Aragona University Hospital University of Salerno  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Field","sequence":"additional","affiliation":[{"name":"School of Medicine University of New South Wales\u2010Sydney, and St Vincents Hospital  Sydney New South Wales Australia"},{"name":"School of Medicine University of Notre Dame University\u2010Sydney and St Vincents Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"WHO Reporting System for Lymph Node, Spleen, and Thymus Cytopathology","author":"WHO Reporting System for Lymph Node","year":"2024"},{"key":"e_1_2_6_3_1","volume-title":"Lymph Node and Spleen Cytohistology","author":"Field 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