{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:18:04Z","timestamp":1783113484858,"version":"3.54.6"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The majority of oral cancers are diagnosed at an advanced stage. It has been demonstrated that the implementation of screening programs reduces mortality rates. Oral cytology is a technique that is used in these programs. However, the accuracy of oral cytology remains controversial. Therefore, the objective of this meta\u2010analysis was to validate the accuracy of oral cytology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search was conducted in the PubMed, Embase, and Cochrane Library databases to identify eligible studies. The inclusion criteria were as follows: studies that evaluated the diagnostic accuracy of oral cytology for low\u2010grade squamous intraepithelial lesion or worse. The article incorporated peer\u2010reviewed articles. In addition, studies that provided sufficient data for conducting a meta\u2010analysis were assessed. The meta\u2010analysis was conducted using a bivariate random\u2010effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 26 articles comprising 8397 specimens were included in the study. The meta\u2010analysis yielded a pooled sensitivity of 93.8% and a pooled specificity of 87.7% of oral cytology for identifying oral epithelia dysplasia or worse. A subgroup analysis of studies that evaluated oral cytology with Papanicolaou staining demonstrated a pooled sensitivity of 94.8%. The accuracy of oral cytology in detecting high\u2010grade squamous intraepithelial lesion or worse was examined, resulting in a pooled sensitivity of 95.7%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta\u2010analysis indicated that oral cytology exhibited high sensitivity and specificity in detecting oral epithelia dysplasia or worse, with slightly higher sensitivity for high\u2010grade squamous intraepithelial lesion or worse. A notable advantage of using oral cytology with Papanicolaou staining is the potential for enhanced sensitivity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncy.70088","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:39:51Z","timestamp":1773815991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical utility of oral cytology for detecting oral epithelial dysplasia or worse: A diagnostic meta\u2010analysis"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3748-856X","authenticated-orcid":false,"given":"Cheng\u2010Chieh","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pathology St Paul's Hospital  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke\u2010Yu","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory 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